Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013:2013:502697.
doi: 10.1155/2013/502697. Epub 2013 Dec 24.

The Effects of Antipsychotics on Prolactin Levels and Women's Menstruation

S I Bargiota  1 , K S Bonotis  1 , I E Messinis  2 , N V Angelopoulos  1
Affiliations
Review

The Effects of Antipsychotics on Prolactin Levels and Women's Menstruation

S I Bargiota et al. Schizophr Res Treatment. 2013.

Abstract

Introduction. Typical and atypical antipsychotic agent is currently used for treatment in the majority of patients with psychotic disorders. The aim of this review is to assess antipsychotic induced hyperprolactinaemia and the following menstrual dysfunction that affects fertility, quality of life, and therapeutic compliance of women. Method. For this purpose, Medline, PsychInfo, Cochrane library, and Scopus databases were accessed, with a focus on the publication dates between 1954 and 2012. Research of references was also performed and 78 studies were retrieved and used for the needs of this review. Results. A summary of several antipsychotics as well as frequency rates and data on hyperprolactinaemia and menstrual disorders for different agent is presented. Conclusion. Diverse prevalence rates of hyperprolactinaemia and menstrual abnormalities have been found about each medication among different studies. Menstruation plays an important role for women, thus, understanding, careful assessment, and management of hyperprolactinaemia could enhance their lives, especially when dealing with women that suffer from a psychotic disorder.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Reasons for hyperprolactinaemia and its side effects.
Figure 2
Figure 2
Physiological status of GnRH pulsatile secretion.
See this image and copyright information in PMC

References

    1. Dickson RA, Glazer WM. Neuroleptic-induced hyperprolactinaemia. Schizophrenia Research. 1999;(35):575–586. - PubMed
    1. Peuskens J, Sienaert P, de Hert M. Sexual dysfunction: the unspoken side effect of antipsychotics. European Psychiatry. 1998;13(1):23–30. - PubMed
    1. Knegtering H, van der Moolen AEGM, Castelein S, Kluiter H, van den Bosch RJ. What are the effects of antipsychotics on sexual dysfunctions and endocrine functioning? Psychoneuroendocrinology. 2003;28(2):109–123. - PubMed
    1. Canuso CM, Goldstein JM, Wojcik J, et al. Antipsychotic medication, prolactin elevation, and ovarian function in women with schizophrenia and schizoaffective disorder. Psychiatry Research. 2002;111(1):11–20. - PubMed
    1. Brunelleschi S, Zeppegno P, Risso F, Cattaneo CI, Torre E. Risperidone-associated hyperprolactinemia: evaluation in twenty psychiatric outpatients. Pharmacological Research. 2003;48(4):405–409. - PubMed

LinkOut - more resources