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. 2014 Apr;1845(2):232-47.
doi: 10.1016/j.bbcan.2014.01.008. Epub 2014 Jan 31.

The role of key genes and pathways involved in the tumorigenesis of Malignant Mesothelioma

Leonardo Vinícius Monteiro de Assis  1 , Jamille Locatelli  2 , Mauro César Isoldi  3
Affiliations

The role of key genes and pathways involved in the tumorigenesis of Malignant Mesothelioma

Leonardo Vinícius Monteiro de Assis et al. Biochim Biophys Acta. 2014 Apr.

Abstract

Malignant Mesothelioma (MM) is a very aggressive cancer with low survival rates and often diagnosed at an advanced stage. Several players have been implicated in the development of this cancer, such as asbestos, erionite and the simian virus 40 (SV40). Here, we have reviewed the involvement of erionite, SV40, as well as, the role of several genes (p16(INK4a), p14(ARF), NF2, LATS2, SAV, CTNNB1 and among others), the pathways (RAS, PI3K, Wnt, BCL and Hippo), and their respective roles in the development of MM.

Keywords: Erionite/SV40; Genes and pathways; Malignant Mesothelioma; NF2; PI3K/AKT; p16(INK4a)/p(14ARF).

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