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Review
. 2014 Feb;20(1 Neurology of Pregnancy):60-79.
doi: 10.1212/01.CON.0000443837.95260.af.

Pregnancy and epilepsy

Cynthia L Harden
Review

Pregnancy and epilepsy

Cynthia L Harden. Continuum (Minneap Minn). 2014 Feb.

Abstract

Purpose of review: This review encompasses issues regarding the management of women with epilepsy and pregnancy, including preconception planning, antiepileptic drug (AED) effects on the exposed offspring, and consequences of seizures during pregnancy, with an emphasis on counseling points and risk management.

Recent findings: In utero valproate exposure continues to show the highest risk of congenital malformations and of adverse cognitive outcomes, including autism, compared to other AEDs. In utero topiramate exposure is associated with facial clefts. In utero exposure to lamotrigine, carbamazepine, phenytoin, and levetiracetam has been evaluated in large numbers of offspring, and all of these AEDs have a low risk of major congenital malformations, near 2.5%. The risk of major congenital malformations due to in utero AED exposure is dose associated. Folic acid taken at the time of conception decreases the risk of adverse cognitive outcomes. AED polytherapy may adversely affect fertility, and in utero exposure of AED polytherapy is associated with infants who are small for their gestational age. Seizure freedom before pregnancy is a good predictor of remaining seizure free during pregnancy.

Summary: Counseling points are complex for managing women with epilepsy contemplating pregnancy, including evaluation of AED choice and dose. The physician must have knowledge of the issues to enable an honest discussion and appropriate decision making in partnership with the patient.

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Figures

Figure 3-1.
Figure 3-1.
North American AED Pregnancy Registry between 1997 and 2011. Percent of major congenital malformations and 95% confidence interval with monotherapy in first trimester exposure. CBZ = carbamazepine; VPA = valproate; LTG = lamotrigine; PHT = phenytoin; OXC = oxcarbazepine; GBP = gabapentin; PB = phenobarbital; ZNS = zonisamide; TPM = topiramate; CZP = clonazepam; LVT = levetiracetam. Data from Hernández-Díaz S, et al, Neurology. www.neurology.org/content/78/21/1692.abstract?sid=4a54bb28-bec2-496a-8fcb-e348d3da2b98.
See this image and copyright information in PMC

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