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. 2014 Apr;31(4):477-84.
doi: 10.1007/s10815-014-0181-8. Epub 2014 Feb 4.

Efficacy, safety, and trends in assisted reproductive technology in Japan-analysis of four-year data from the national registry system

Kazumi Takeshima  1 , Hidekazu Saito, Aritoshi Nakaza, Akira Kuwahara, Osamu Ishihara, Minoru Irahara, Humiki Hirahara, Yasunori Yoshimura, Tetsuro Sakumoto
Affiliations

Efficacy, safety, and trends in assisted reproductive technology in Japan-analysis of four-year data from the national registry system

Kazumi Takeshima et al. J Assist Reprod Genet. 2014 Apr.

Abstract

Purpose: This study aimed to evaluate the efficacy, safety, and trends in assisted reproductive technology (ART) in Japan.

Methods: Data pertaining to treatment cycles, pregnancy rate, live birth rate, age distribution, single embryo transfer rate, and multiple pregnancy rate were analyzed for patients registered in the national ART registry system of Japan from 2007 to 2010.

Results: The total number of treatment cycles was 161,164, 190,613, 213,800, and 242,161 in 2007, 2008, 2009, and 2010, respectively. The number of ART treatments administered to patients aged ≥40 years was 31.2 %, 32.1 %, 33.4 %, and 35.7 %, respectively, showing an increasing trend from 2007 to 2010. In each of these years, the total pregnancy rate per embryo transfer was 24.4 %, 21.9 %, 22.3 %, and 21.9 % for fresh cycles, respectively, and 32.0 %, 32.1 %, 32.5 %, and 33.7 % for frozen cycles, respectively. The single embryo transfer rate was 49.9 %, 63.6 %, 70.6 %, and 73.0 %, respectively, showing an increasing trend, while the multiple pregnancy rate was 11.5 %, 6.8 %, 5.3 %, and 4.8 %, respectively, showing a decreasing trend.

Conclusions: From 2007 to 2010 in Japan, the number of ART treatment cycles, number of elderly patients treated, and the single embryo transfer rate increased, while the multiple pregnancy rate decreased. However, the overall pregnancy rate remained stable during the study period.

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Figures

Fig. 1
Fig. 1
Age distribution for ART treatment each year (2007–2010) in Japan. Note: Age distribution for ART treatment from 2007 to 2010
Fig. 2
Fig. 2
Pregnancy rate by age each year (2007–2010) in Japan. Note: Pregnancy rate by age from 2007 to 2010
Fig. 3
Fig. 3
SET rate, pregnancy rate with fresh and frozen cycles, and the total multiple pregnancy rate each year (2007–2010) in Japan. Note: The pregnancy rate is calculated per ET
See this image and copyright information in PMC

References

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