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. 2013 Dec;30(6):343-9.
doi: 10.5114/pdia.2013.39432. Epub 2013 Dec 18.

Evaluation of biophysical skin parameters and assessment of hair growth in patients with acne treated with isotretinoin

Małgorzata L Kmieć  1 , Anna Pajor  1 , Grażyna Broniarczyk-Dyła  1
Affiliations

Evaluation of biophysical skin parameters and assessment of hair growth in patients with acne treated with isotretinoin

Małgorzata L Kmieć et al. Postepy Dermatol Alergol. 2013 Dec.

Abstract

Introduction: Treatment of the severe forms of acne vulgaris remains a challenge. Isotretinoin is a drug often used in these cases. Retinoids affect the mechanisms that play a role in the pathogenesis of acne, reduce the production of sebum and sizes of the sebaceous glands. However, isotretinoin appears to have undesirable side effects in the skin, mucous membranes and hair.

Aim: THE AIM OF THIS STUDY WAS TO ASSESS THE EFFECT OF ACNE VULGARIS TREATMENT WITH ISOTRETINOIN ON BIOPHYSICAL SKIN PARAMETERS: skin sebum and stratum corneum hydration levels, transepidermal water loss values, pH, erythema and hair growth parameters: total number, density and proportion of anagen hair.

Material and methods: THE STUDY INCLUDED THIRTY PATIENTS WITH ACNE TYPES: papulopustular, conglobata and phlegmonosa. Patients were treated with isotretinoin at a dose of 0.5-1.0 mg/kg/day for a period of 4-7 months. The measurements of skin biophysical parameters were performed before and after the treatment using Sebumeter SM815, Corneometer CM825, Tewameter TM300, MX Mexameter MX18 and Skin-pH-Meter PH908. Hair growth parameters were evaluated with FotoFinder Dermoscope using the TrichoScan Professional V3.0.8.76 software.

Results: The results of biophysical skin parameter measurements after the treatment showed a reduction in the severity of seborrhea. However, the skin was dry, which confirmed a lowered degree of stratum corneum hydration and an increase in transepidermal water loss values. Moreover, severity of erythema, an increase in pH value, and variations in selected hair growth parameters: decrease in total count, density and proportion of anagen hair were demonstrated.

Conclusions: The reduction in the skin sebum levels was observed after the treatment. There was dryness of the skin, which was confirmed by biophysical skin parameter measurements. Changes in the hair growth parameters showed telogen effluvium hair loss.

Keywords: acne vulgaris; biophysical skin parameters; isotretinoin; trichoscan.

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Figures

Figure 1
Figure 1
Results of digital TrichoScan analysis within the study scalp area
Figure 2
Figure 2
Comparison of biophysical skin parameters before and after the treatment (p < 0.001)
Figure 3
Figure 3
Comparison of hair growth parameters in the study group
Figure 4
Figure 4
Skin and mucosal dryness after the treatment with isotretinoin
Figure 5
Figure 5
Dryness of the skin associated with isotretinoin therapy
See this image and copyright information in PMC

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