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. 2014 Jan 2;5(2):79-85.
doi: 10.7150/jca.7402. eCollection 2014.

History of dental infections associates with cancer in periodontally healthy subjects: a 24-year follow-up study from sweden

Eunice Virtanen  1 , Birgitta Söder  2 , Leif C Andersson  3 , Jukka H Meurman  4 , Per-Östen Söder  2
Affiliations

History of dental infections associates with cancer in periodontally healthy subjects: a 24-year follow-up study from sweden

Eunice Virtanen et al. J Cancer. .

Abstract

Background: Infections of teeth are highly prevalent, often leading to tooth extractions. Missing teeth can thus be considered as proxy for chronic dental infections, caries or periodontitis. We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer.

Methods: WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. The subjects appeared periodontally healthy and thus the probable reason for tooth extractions was deep caries. Using Fisher's exact t-test and multiple logistic regression analysis the results were analysed for the association between cancer incidence and baseline oral health parameters and a number of other explanatory factors.

Results: Of the 1 390 subjects 71 had got cancer by year 2009. The results of the multiple regression analysis showed that between any type of cancer as a dependent variable, and several independent explanatory variables, missing second molar in the right mandible and age appeared as the principle independent predictors significantly associating with cancer, with an odds ratio (95% confidence interval) of 2.62 (1.18-5.78) and 1.91 (1.06-3.43), respectively.

Conclusions: In periodontally healthy subjects extracted molars, proxy for past dental infections, seemed to predict cancer risk in the studied age group - hence supporting a role of chronic dental infection/inflammation in carcinogenesis.

Keywords: Cancer.; Dental infections; Extracted molars; Periapical infection.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Study profile.
Figure 2
Figure 2
Explanatory pathway for the development of cancer triggered by chronic dental infections.
See this image and copyright information in PMC

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References

    1. Trovik TA, Klock KS, Haugejorden O. Trends in reasons for tooth extractions in Norway from 1968 to 1998. Acta Odontol Scand. 2000 Apr;58(2):89–96. - PubMed
    1. Spalj S, Plancak D, Juric H, Pavelic B, Bosnjak A. Reasons for extraction of permanent teeth in urban and rural populations of Croatia. Coll Antropol. 2004 Dec;28(2):833–839. - PubMed
    1. Chrysanthakopoulos NA. Reasons for extraction of permanent teeth in Greece: a five-year follow-up study. Int Dent J. 2011 Feb;61(1):19–24. - PMC - PubMed
    1. Fischetti VA. Novel method to control pathogenic bacteria on human mucous membranes. Ann N Y Acad Sci. 2003 Apr;987:207–214. - PubMed
    1. Tachibana M, Yoshida A, Ansai T, Takata Y, Akifusa S, Fukuhara M. et al. Prevalence of periodontopathic bacteria on the tongue dorsum of elderly people. Gerodontology. 2006 Jun;23(2):123–126. - PubMed