Reply to Struys: Role of biomarker of 2-hydroxyglutarate in acute myeloid leukemia
- PMID: 24494222
- PMCID: PMC3870698
- DOI: 10.1073/pnas.1319936110
Reply to Struys: Role of biomarker of 2-hydroxyglutarate in acute myeloid leukemia
Conflict of interest statement
The authors declare no conflict of interest.
Comment on
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Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China.Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17017-22. doi: 10.1073/pnas.1315558110. Epub 2013 Sep 30. Proc Natl Acad Sci U S A. 2013. PMID: 24082129 Free PMC article. Clinical Trial.
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2-Hydroxyglutarate is not a metabolite; D-2-hydroxyglutarate and L-2-hydroxyglutarate are!Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E4939. doi: 10.1073/pnas.1318777110. Epub 2013 Dec 6. Proc Natl Acad Sci U S A. 2013. PMID: 24319093 Free PMC article. No abstract available.
References
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- Van Schaftingen E, Rzem R, Veiga-da-Cunha M. L: -2-Hydroxyglutaric aciduria, a disorder of metabolite repair. J Inherit Metab Dis. 2009;32(2):135–142. - PubMed
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- Sellner L, et al. Increased levels of 2-hydroxyglutarate in AML patients with IDH1-R132H and IDH2-R140Q mutations. Eur J Haematol. 2010;85(5):457–459. - PubMed
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