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. 2014 Feb;27(1):20-5.
doi: 10.1089/vim.2013.0097.

The relation of plasmacytoid dendritic cells (pDCs) and regulatory T-cells (Tregs) with HPV persistence in HIV-infected and HIV-uninfected women

Howard D Strickler  1 , Jeffrey Martinson, Seema Desai, Xianhong Xie, Robert D Burk, Kathryn Anastos, L Stewart Massad, Howard Minkoff, Xiaonan Xue, Gypsyamber D'Souza, Alexandra M Levine, Christine Colie, D Heather Watts, Joel M Palefsky, Alan Landay
Affiliations

The relation of plasmacytoid dendritic cells (pDCs) and regulatory T-cells (Tregs) with HPV persistence in HIV-infected and HIV-uninfected women

Howard D Strickler et al. Viral Immunol. 2014 Feb.

Abstract

Other than CD4+ count, the immunologic factors that underlie the relationship of HIV/AIDS with persistent oncogenic HPV (oncHPV) and cervical cancer are not well understood. Plasmacytoid dendritic cells (pDCs) and regulatory T-cells (Tregs) are of particular interest. pDCs have both effector and antigen presenting activity and, in HIV-positive patients, low pDC levels are associated with opportunistic infections. Tregs downregulate immune responses, and are present at high levels in HIV-positives. The current pilot study shows for the first time that low pDC and high Treg levels may be significantly associated with oncHPV persistence in both HIV-positive and HIV-negative women. Larger studies are now warranted.

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