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. 2014 Feb 21;16(4):1060-3.
doi: 10.1021/ol403591c. Epub 2014 Feb 5.

Mild and selective heterogeneous catalytic hydration of nitriles to amides by flowing through manganese dioxide

Claudio Battilocchio  1 , Joel M Hawkins, Steven V Ley
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Mild and selective heterogeneous catalytic hydration of nitriles to amides by flowing through manganese dioxide

Claudio Battilocchio et al. Org Lett. .

Abstract

A sustainable flow chemistry process for the hydration of nitriles, whereby an aqueous solution of the nitrile is passed through a column containing commercially available amorphous manganese dioxide, has been developed. The product is obtained simply by concentration of the output stream without any other workup steps. The protocol described is rapid, robust, reliable, and scalable, and it has been applied to a broad range of substrates, showing a high level of chemical tolerance.

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