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. 2014 Mar;23(1):19-20.
doi: 10.1017/S204579601300070X.

Do antidepressants prolong the QT interval?

M Nosè  1 , C Barbui  1
Affiliations

Do antidepressants prolong the QT interval?

M Nosè et al. Epidemiol Psychiatr Sci. 2014 Mar.

Abstract

According to a recent cross-sectional study, some antidepressants, including amitriptyline, citalopram and escitalopram, are associated with QTc prolongation. However, the magnitude of this association is relatively small, and the clinical implications uncertain. In this article, the main strengths and weaknesses of this cross-sectional study are briefly analysed alongside recent warnings issued by regulatory authorities. Implications for research and practice are discussed.

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References

    1. Barbui C, Cipriani A (2011). What are evidence-based treatment recommendations? Epidemiology and Psychiatric Sciences 20, 29–31. - PubMed
    1. Castro VM, Clements CC, Murphy SN, Gainer VS, Fava M, Weilburg JB, Erb JL, Churchill SE, Kohane IS, Iosifescu DV, Smoller JW, Perlis RH (2013). QT interval and antidepressant use: a cross sectional study of electronic health records. British Medical Journal 346, f288. - PMC - PubMed
    1. Food and Drug Administration (2011). FDA Drug Safety Communication: abnormal heart rhythms associated with high doses of Celexa (citalopram hydrobromide). MedWatch http://www.fda.gov.
    1. Reilly JG, Ayis SA, Ferrier IN, Jones SJ, Thomas SHL (2000). QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients. Lancet 355, 1048–1052. - PubMed
    1. Roden DM (2004). Drug-induced prolongation of the QT interval. New England Journal of Medicine 350, 1013–1022. - PubMed