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Review
. 2014 Jun-Aug;53(1-2):77-83.
doi: 10.1016/j.bcmd.2014.01.001. Epub 2014 Feb 2.

BRAF--a new player in hematological neoplasms

Marcin M Machnicki  1 , Tomasz Stoklosa  2
Affiliations
Review

BRAF--a new player in hematological neoplasms

Marcin M Machnicki et al. Blood Cells Mol Dis. 2014 Jun-Aug.

Abstract

BRAF oncogenic kinase has become a target for specific therapy in oncology. Genetic characterization of a predominant V600E mutation in melanoma, thyroid cancer, and other tumors became a focus for developing specific inhibitors, such as vemurafenib or dabrafenib. Our knowledge regarding the role of mutated BRAF in hematological malignancies has grown quickly as a result of new genetic techniques such as next-generation sequencing. This review summarizes current knowledge regarding the role of BRAF in lymphoid and myeloid neoplasms, with a focus on hairy-cell leukemia, Langerhans cell histiocytosis, and Erdheim-Chester disease.

Keywords: BRAF kinase; Histiocytosis; Leukemia; V600E mutation.

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