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Randomized Controlled Trial
. 2014 Mar 4;110(5):1334-7.
doi: 10.1038/bjc.2014.38. Epub 2014 Feb 4.

Effect of oral anticoagulants on the outcome of faecal immunochemical test

L Bujanda  1 , C Sarasqueta  2 , Á Lanas  3 , E Quintero  4 , J Cubiella  5 , V Hernandez  6 , J D Morillas  7 , T Perez-Fernández  8 , D Salas  9 , M Andreu  10 , F Carballo  11 , X Bessa  10 , I Portillo  12 , R Jover  13 , F Balaguer  14 , A Cosme  1 , A Castells  14 ; COLONPREV study investigators
Collaborators, Affiliations
Randomized Controlled Trial

Effect of oral anticoagulants on the outcome of faecal immunochemical test

L Bujanda et al. Br J Cancer. .

Abstract

Background: We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening.

Methods: Individuals aged 50-69 years were invited to receive one FIT sample (cutoff 75 ng ml(-1)) between November 2008 and June 2011.

Results: Faecal immunochemical test was positive in 9.3% (21 out of 224) of users of OAC and 6.2% (365 out of 5821) of non-users (P-trend=0.07). The positive predictive value (PPV) for advanced neoplasia (AN) in non-users was 50.4% vs 47.6% in users (odds ratio, 0.70; 95% CI, 0.3-1.8; P=0.5). The PPV for AN in OAC more antiplatelets (aspirin or clopidogrel) was 75% (odds ratio, 2; 95% CI, 0.4-10.8; P=0.4).

Conclusions: Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program. The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets.

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Figures

Figure 1
Figure 1
Study recruitment and participant flow.
See this image and copyright information in PMC

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