Comparison of slit lamp-adapted optical coherence tomography features of fellow eyes of acute primary angle closure and eyes with open angle glaucoma

Abstract

Purpose: The aim of this study was to assess the possibility of discriminating a narrow and occludable chamber angle by means of digital gonioscopy.

Methods: In a prospective controlled clinical study 40 eyes of 40 patients were enrolled. 20 patients that had suffered acute angle closure glaucoma (ACG) on the fellow eye were compared to 20 patients with open angle glaucoma (OAG). Anterior segment imaging with SL-OCT (Heidelberg Engineering, Heidelberg, Germany) enabled the delineation, by means of automatic signal analysis, of several important parameters of the anterior chamber angle region, which were compared to those revealed from direct contact glass gonioscopy and ultrasound biometry.

Results: The anterior segment structures were automatically recognized by the SL-OCT software in 70 % of the ACG patients and in all of the OAG cases (100 %) (p = 0.025). Anterior chamber angle (ACA) was 15.55° ± 6.92° in the ACG group and 34.6° ± 8.9° in the OAG group, whereas angle opening distance (AOD) was 199.55 ± 62.29 μm in ACG and 452.67 ± 123.91 μm in OAG. A good correlation was found in the direct gonioscopic findings (r = 0.85, p < 0.001), but there were significant differences between both groups (p < 0.001). Mean real central anterior chamber depth (rACD) was evaluated to be 1.75 and 2.79 mm in ACG and OAG, respectively, showing a significant difference (p < 0.0001) and the highest (although not statistically significant) sensitivity and specificity above all other parameters tested in discriminating between OAG and ACG eyes. Discrimination criteria revealed a relevant narrowing of the anterior chamber angle region for values below 22° (ACA), 276 μm (AOD) and 2.08 mm (rACD).

Conclusions: Digital gonioscopy by means of SL-OCT allowed a non-invasive and objective imaging of the anterior chamber configuration that could be used as a screening method for narrow and occludable angles. The method could contribute to a timely identification of angle closure and alert clinicians to further determine whether a peripheral iridotomy should be performed.