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Comment
. 2014 Apr;29(4):784-6.
doi: 10.1002/jbmr.2189.

Biomechanical mechanisms: resolving the apparent conundrum of why individuals with type II diabetes show increased fracture incidence despite having normal BMD

Karl J Jepsen  1 , Stephen H Schlecht
Affiliations
Comment

Biomechanical mechanisms: resolving the apparent conundrum of why individuals with type II diabetes show increased fracture incidence despite having normal BMD

Karl J Jepsen et al. J Bone Miner Res. 2014 Apr.
No abstract available

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Figures

Fig. 1
Fig. 1
Examples of different biomechanical pathways (mechanisms) leading to the reduced fracture resistance of aging bone relative to applied loads. Most investigators are familiar with the low bone mass path (bold). The article by Farr and colleagues(1) highlights the existence of other known paths (eg, diet→cross-link→reduced toughness; dashed arrows) that also compromise fracture resistance and which may help explain the increased fracture risk of T2D patients.
See this image and copyright information in PMC

Comment on

References

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    1. Patsch JM, Burghardt AJ, Yap SP, et al. Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures. J Bone Miner Res. 2013;28(2):313–24. - PMC - PubMed
    1. Currey JD. The effect of porosity and mineral content on the Young's modulus of elasticity of compact bone. J Biomech. 1988;21(2):131–9. - PubMed
    1. Saito M, Marumo K. Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus. Osteoporos Int. 2010;21(2):195–214. - PubMed
    1. Turner CH, Burr DB. Basic biomechanical measurements of bone: a tutorial. Bone. 1993;14(4):595–608. - PubMed