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Review
. 2014 Jan;30(1):2-7.
doi: 10.4103/0970-1591.124197.

Risks of testosterone replacement therapy in men

Affiliations
Review

Risks of testosterone replacement therapy in men

E Charles Osterberg et al. Indian J Urol. 2014 Jan.

Abstract

Testosterone replacement therapy (TRT) is a widely used treatment for men with symptomatic hypogonadism. The benefits seen with TRT, such as increased libido and energy level, beneficial effects on bone density, strength and muscle as well as cardioprotective effects, have been well-documented. TRT is contraindicated in men with untreated prostate and breast cancer. Men on TRT should be monitored for side-effects such as polycythemia, peripheral edema, cardiac and hepatic dysfunction.

Keywords: Hypogonadism; side-effects; testosterone replacement therapy.

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Conflict of interest statement

Conflict of Interest: None declared.

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References

    1. Gruenewald DA, Matsumoto AM. Testosterone supplementation therapy for older men: Potential benefits and risks. J Am Geriatr Soc. 2003;51:101–15. - PubMed
    1. Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR Baltimore Longitudinal Study of Aging. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore longitudinal study of aging. J Clin Endocrinol Metab. 2001;86:724–31. - PubMed
    1. Basaria S, Dobs AS. Risks versus benefits of testosterone therapy in elderly men. Drugs Aging. 1999;15:131–42. - PubMed
    1. Surampudi PN, Wang C, Swerdloff R. Hypogonadism in the aging male diagnosis, potential benefits, and risks of testosterone replacement therapy. Int J Endocrinol 2012. 2012:1–52. - PMC - PubMed
    1. Shigehara K, Namiki M. Late-onset hypogonadism syndrome and lower urinary tract symptoms. Korean J Urol. 2011;52:657–63. - PMC - PubMed