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. 2013 Oct 1;2(4):e25352.
doi: 10.4161/jkst.25352. Epub 2013 Jun 10.

A novel role for STAT5 in DC: Controlling the Th2-response

Aurélie Jeanne Tormo  1 , Jean-François Gauchat  1
Affiliations

A novel role for STAT5 in DC: Controlling the Th2-response

Aurélie Jeanne Tormo et al. JAKSTAT. .

Abstract

Dendritic cells (DC) play a key role in immunity by recognizing and presenting antigens. Cytokines and cytokine-activated transcription factors are fundamental in the regulation of the DC differentiation and their functions. While the role of STAT3 in DC development is well established, the function of STAT5 in DC has yet to be fully elucidated. A recent study published in Nature Immunology by Bell et al., using the DC-specific deletion of Stat5, demonstrated the importance of STAT5 in the induction of a Th2 response in DC. As the activation of this transcription factor is not required for the induction of a Th1 response, the authors further investigated the role STAT5 in the signaling to thymic stromal lymphopoietin (TSLP), a cytokine known to be important for type 2 inflammatory responses. Their results demonstrate the importance of STAT5 activation during TLSP-induced Th2 responses and suggest that DC are a key TLSP target.

Keywords: CD11c-Cre Stat5fl/fl mice; STAT5; TSLP; Th2 induced response; dendritic cells.

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Figures

None
Figure 1. Importance of STAT5 in TSLP-activated DC. The study by Bell et al. demonstrates the role of STAT5 activation by TSLP in DC. This STAT5 activation induces an upregulation of costimulation molecules like CD80, CD86, or OX40L; associated to a CCL17 production. TSLP-induced STAT5 activation mediates Th2 responses by CD4 T cells.
See this image and copyright information in PMC

Comment on

  • Bell BD, Kitajima M, Larson RP, Stoklasek TA, Dang K, Sakamoto K, Wagner KU, Kaplan DH, Reizis B, Hennighausen L, et al. The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses. Nat Immunol. 2013;14:364–71. doi: 10.1038/ni.2541. doi: 10.1038/ni.2541

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