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. 2013 Oct 1;2(10):e25911.
doi: 10.4161/onci.25911. Epub 2013 Aug 2.

A new mouse model of inflammation and gastric cancer

Thanh-Long M Nguyen  1 , Richard J Dipaolo  1
Affiliations

A new mouse model of inflammation and gastric cancer

Thanh-Long M Nguyen et al. Oncoimmunology. .

Abstract

Chronic inflammation increases the risk of developing several malignancies, including gastric cancer. A better understanding of how inflammation promotes gastric oncogenesis is therefore urgently needed. We have recently developed and characterized a mouse model that will be useful to elucidate the molecular and cellular circuitries bridging inflammation and gastric cancer.

Keywords: autoimmune gastritis; gastric cancer; gastric epithelial cells; inflammation; mouse models.

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Figures

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Figure 1. Inflammation-induced gastric carcinogenesis in TxA23 mice mimics several aspects of the corresponding human condition. In TxA23 mice, the source of the chronic inflammatory state that alters the normal gastric epithelium is represented by the self-reactive CD4+ T cells that cause autoimmune gastritis. TxA23 mice not only develop oxyntic atrophy and spasmolytic polypeptide-expressing metaplasia (SPEM), but also express several biomarkers that have been associated with human gastric cancer. Ultimately, by 12 months of age, TxA23 mice exhibit severe dysplasia and gastric intraepithelial neoplasms.
See this image and copyright information in PMC

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