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. 2014 Feb 6;370(6):584-5.
doi: 10.1056/NEJMc1311092.

Abnormal ventilatory responses in adults born prematurely

Melissa L Bates  1 , Emily T Farrell, Marlowe W Eldridge
Affiliations

Abnormal ventilatory responses in adults born prematurely

Melissa L Bates et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Ventilatory Responses to Hypoxia and Hyperoxia in Adults Born Prematurely as Compared with Adults Born at Full Term
All full-term adults (controls) had increased ventilation in response to hypoxia (fraction of inspired oxygen [FIO2] = 0.10); paradoxically, some preterm adults hypoventilated in response to hypoxia and reported presyncopal symptoms at the end of the trial (Panel A; boxes depict the median and first and third interquartile ranges, with whiskers indicating maximum and minimum responses). After 60 seconds of hyperoxia (FIO2 = 1.0), ventilation was depressed in all full-term adults, but this response was blunted in preterm adults (Panel B; points represent the mean ±SD). The blunting of hyperoxic and hypoxic ventilatory responses was correlated in preterm adults, suggesting a common cause of ventilatory dysfunction (Panel C). The Δ symbol denotes change, SpO2 oxygen saturation as measured by pulse oximetry, and V˙E volume expired.
See this image and copyright information in PMC

References

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