Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Mar;19(2):95-108.
doi: 10.3109/1354750X.2014.881418. Epub 2014 Feb 5.

Biomarkers as outcome predictors in subarachnoid hemorrhage--a systematic review

Affiliations

Biomarkers as outcome predictors in subarachnoid hemorrhage--a systematic review

Caron M Hong et al. Biomarkers. 2014 Mar.

Abstract

Context: Subarachnoid hemorrhage (SAH) has a high fatality rate and many suffer from delayed neurological deficits. Biomarkers may aid in the identification of high-risk patients, guide treatment/management and improve outcome.

Objective: The aim of this review was to summarize biomarkers of SAH associated with outcome.

Methods: An electronic database query was completed, including an additional review of reference lists to include all potential human studies.

Results: A total of 298 articles were identified; 112 were reviewed; 55 studies were included.

Conclusion: This review details biomarkers of SAH that correlate with outcome. It provides the basis for research investigating their possible translation into the management of SAH patients.

PubMed Disclaimer

Conflict of interest statement

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Figures

Figure 1
Figure 1
Search results.

References

    1. Badjatia N, Carpenter A, Fernandez L, et al. Relationship between C-reactive protein, systemic oxygen consumption, and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Stroke. 2011;42:2436–2442. - PubMed
    1. Bernabeu C, Conley BA, Vary CP. Novel biochemical pathways of endoglin in vascular cell physiology. J Cell Biochem. 2007;102:1375–1388. - PMC - PubMed
    1. Carmeliet P, Collen D. Vascular development and disorders: molecular analysis and pathogenic insights. Kidney Int. 1998;53:1519–1549. - PubMed
    1. Cengiz SL, Ak A, Ustun ME, Karakose S. Lactate contents from cerebrospinal fluid in experimental subarachnoid hemorrhage, well correlate with vasospasm: ongoing and neurologic status. J Neurosurg Anesthesiol. 2007;19:166–170. - PubMed
    1. Chou SH, Feske SK, Atherton J, et al. Early elevation of serum tumor necrosis factor-alpha is associated with poor outcome in subarachnoid hemorrhage. J Investig Med. 2012;60:1054–1058. - PMC - PubMed

Publication types