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Review
. 2014 Mar;12(1):1-8.
doi: 10.1007/s11914-014-0195-2.

Bone and the innate immune system

Julia F Charles  1 , Mary C Nakamura
Affiliations
Review

Bone and the innate immune system

Julia F Charles et al. Curr Osteoporos Rep. 2014 Mar.

Abstract

The immune system and bone are intimately linked with significant physical and functionally related interactions. The innate immune system functions as an immediate response system to initiate protections against local challenges such as pathogens and cellular damage. Bone is a very specific microenvironment, in which infectious attack is less common but repair and regeneration are ongoing and important functions. Thus, in the bone the primary goal of innate immune and bone interactions is to maintain tissue integrity. Innate immune signals are critical for removal of damaged and apoptotic cells and to stimulate normal tissue repair and regeneration. In this review we focus on the innate immune mechanisms that function to regulate bone homeostasis.

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Conflict of interest statement

Conflict of Interest

JF Charles declares no conflicts of interest.

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