Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1988 Apr;56(4):898-902.
doi: 10.1128/iai.56.4.898-902.1988.

Establishment of a monoclonal antibody recognizing an antigenic site common to Clostridium botulinum type B, C1, D, and E toxins and tetanus toxin

K Tsuzuki  1 , N Yokosawa, B Syuto, I Ohishi, N Fujii, K Kimura, K Oguma
Affiliations
Comparative Study

Establishment of a monoclonal antibody recognizing an antigenic site common to Clostridium botulinum type B, C1, D, and E toxins and tetanus toxin

K Tsuzuki et al. Infect Immun. 1988 Apr.

Abstract

The partial amino acid sequence of the light-chain (Lc) component of Clostridium botulinum type C1 toxin was determined. The sequence was quite similar to those of the other types of botulinum and tetanus toxins. Nine monoclonal antibodies against botulinum type E toxin were established by immunizing BALB/c mice with type E toxoid or its Lc component. Six antibodies reacted with the heavy-chain component and three reacted with the Lc component of the toxin. One of the latter three antibodies reacted with botulinum type B, C1, and D toxins and tetanus toxin, as well as botulinum type E toxin. This antibody recognized the Lc components of these toxins, indicating that there exists one common antigenic determinant on the Lc regions of these toxins.

PubMed Disclaimer

References

    1. J Gen Microbiol. 1986 Jul;132(7):1981-8 - PubMed
    1. Infect Immun. 1980 Dec;30(3):668-73 - PubMed
    1. Infect Immun. 1982 Oct;38(1):14-20 - PubMed
    1. Infect Immun. 1984 Feb;43(2):487-90 - PubMed
    1. Nature. 1970 Aug 15;227(5259):680-5 - PubMed

Publication types

MeSH terms

LinkOut - more resources