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Comment
. 2014 Feb 18;111(7):2404-5.
doi: 10.1073/pnas.1324286111. Epub 2014 Feb 5.

LILR-B1 blocks activating FcγR signaling to allow antibody dependent enhancement of dengue virus infection

Falk Nimmerjahn  1 , Anja Lux
Affiliations
Comment

LILR-B1 blocks activating FcγR signaling to allow antibody dependent enhancement of dengue virus infection

Falk Nimmerjahn et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
The role of LILR-B1 in enhancement of dengue virus infection. Shown is the interaction of dengue virus opsonized either under subneutralizing (Left) or high antidengue IgG conditions (Right). Whereas high antidengue IgG levels result in the dominant triggering of activating FcγRs and the expression of ISGs, low IgG levels result in additional binding of dengue virus to LILR-B1, which blocks ISG activation via Syk.
See this image and copyright information in PMC

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