Opioid-induced cardioprotection

Abstract

Ischemic heart disease and myocardial infarction continue to be leading causes of cardiovascular morbidity and mortality. Activation of opioid, adenosine, bradykinin, adrenergic and other G-protein coupled receptors has been found to be cardioprotective. κ- and/or δ-opioid receptor activation is involved in direct myocardial protection, while the role of µ-opioid receptors seems less clear. In addition, differential affinities to the three opioid-receptor subtypes by various agonists and cross-talk among different G-protein coupled receptors render conclusions regarding opioid-mediated cardioprotection challenging. The present review will focus on the protective effects of endogenously released opioid peptides as well as exogenously administered opioids such as morphine, fentanyl, remifentanil, butorphanol, and methadone against myocardial ischemia/reperfusion injury. Receptor heterodimerization and cross-talk as well as interactions with other cardioprotective techniques will be discussed. Implications for opioid-induced cardioprotection in humans and for future drug development to improve myocardial salvage will be provided.

Figure 1

Summary of the important signaling pathways involved in mediating opioid-induced cardioprotection. δ-OR = δ-opioid receptor, κ-OR = κ-opioid receptor, μ-OR = μ-opioid receptor, A1 = adenosine A₁-receptor, β = adrenergic β-receptor, SarcK_ATP = sarcolemmal K_ATP channels, mK_ATP = mitochondrial K_ATP channels, mPTP = mitochondrial permeability transition pore, and ROS = reactive oxygen species.