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Observational Study
. 2014 Apr;34(4):301-5.
doi: 10.1038/jp.2014.6. Epub 2014 Feb 6.

Evolving blood pressure dynamics for extremely preterm infants

B Batton  1 , L Li  2 , N S Newman  3 , A Das  4 , K L Watterberg  5 , B A Yoder  6 , R G Faix  6 , M M Laughon  7 , B J Stoll  8 , R D Higgins  9 , M C Walsh  3 ; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Affiliations
Observational Study

Evolving blood pressure dynamics for extremely preterm infants

B Batton et al. J Perinatol. 2014 Apr.

Abstract

Objective: To examine changes in arterial blood pressure (ABP) after birth in extremely preterm infants.

Study design: Prospective observational study of infants 23(0/7) to 26(6/7) weeks gestational age (GA). Antihypotensive therapy use and ABP measurements were recorded for the first 24 h.

Result: A cohort of 367 infants had 18 709 ABP measurements recorded. ABP decreased for the first 3 h, reached a nadir at 4 to 5 h and then increased at an average rate of 0.2 mm Hg h(-1). The rise in ABP from hour 4 to 24 was similar for untreated infants (n=164) and infants given any antihypotensive therapy (n=203), a fluid bolus (n=135) or dopamine (n=92). GA-specific trends were similar. ABP tended to be lower as GA decreased, but varied widely at each GA.

Conclusion: ABP increased spontaneously over the first 24 postnatal hours for extremely preterm infants. The rate of rise in ABP did not change with antihypotensive therapy.

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Figures

Figure 1
Figure 1
Systolic (a), diastolic (b), and mean (c) arterial blood pressure curves over the first 24 hours for extremely preterm infants (n=367)
Figure 2
Figure 2
Gestational age specific changes in the systolic (a), diastolic (b), and mean (c) arterial blood pressure 50th percentile curves over the first 24 hours
See this image and copyright information in PMC

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