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. 2014 May 21;26(19):3024-34.
doi: 10.1002/adma.201304428. Epub 2014 Feb 6.

Macromolecular crowding meets tissue engineering by self-assembly: a paradigm shift in regenerative medicine

Abhigyan Satyam  1 , Pramod Kumar, Xingliang Fan, Alexander Gorelov, Yury Rochev, Lokesh Joshi, Héctor Peinado, David Lyden, Benjamin Thomas, Brian Rodriguez, Michael Raghunath, Abhay Pandit, Dimitrios Zeugolis
Affiliations

Macromolecular crowding meets tissue engineering by self-assembly: a paradigm shift in regenerative medicine

Abhigyan Satyam et al. Adv Mater. .

Abstract

MMC, the addition of inert polydispersed macromolecules in the culture media, effectively emulates the dense in vivo extracellular space, resulting in amplified deposition of ECM in vitro and subsequent production of cohesive, ECM-rich living substitutes.

Keywords: cell-sheet tissue engineering; excluding volume effect; extracellular matrix deposition; macromolecular crowding; macromolecular polydispersity.

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