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Review
. 2014 Jan 15;4(3):240-55.
doi: 10.7150/thno.6914. eCollection 2014.

Current progress in gene delivery technology based on chemical methods and nano-carriers

Lian Jin  1 , Xin Zeng  2 , Ming Liu  1 , Yan Deng  3 , Nongyue He  3
Affiliations
Review

Current progress in gene delivery technology based on chemical methods and nano-carriers

Lian Jin et al. Theranostics. .

Abstract

Gene transfer methods are promising in the field of gene therapy. Current methods for gene transfer include three major groups: viral, physical and chemical methods. This review mainly summarizes development of several types of chemical methods for gene transfer in vitro and in vivo by means of nano-carriers like; calcium phosphates, lipids, and cationic polymers including chitosan, polyethylenimine, polyamidoamine dendrimers, and poly(lactide-co-glycolide). This review also briefly introduces applications of these chemical methods for gene delivery.

Keywords: Chemical Methods.; Gene delivery; Non-viral; Vectors.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Fig 1
Fig 1
Primary physical methods for gene delivery.
Fig 2
Fig 2
Schematic representation of the structure of liposomes.
Fig 3
Fig 3
The schematic presentation of gene delivery process of polymers.
Fig 4
Fig 4
Primary applications of chitosan in biomedical fields.
Fig 5
Fig 5
Schematic representation of proton sponge effect of PEI polymer.
Fig 6
Fig 6
Two forms of PEI. (A) linear PEI, (B) branched PEI.
See this image and copyright information in PMC

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