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. 1988 Mar 22;939(1):163-6.
doi: 10.1016/0005-2736(88)90058-2.

Bupivacaine is an effective potassium channel blocker in heart

K R Courtney  1 , J J Kendig
Affiliations

Bupivacaine is an effective potassium channel blocker in heart

K R Courtney et al. Biochim Biophys Acta. .

Abstract

The local anesthetic agent bupivacaine increases action potential duration in isolated frog atrial myocytes, and blocks two potassium conductances, IK and IK1. The effective concentrations, particularly for IK, are similar to those which depress the sodium conductance. Potassium channel block may thus contribute to bupivacaine's reported cardiotoxicity.

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