Hypothalamic tanycytes: gatekeepers to metabolic control
- PMID: 24506860
- DOI: 10.1016/j.cmet.2014.01.008
Hypothalamic tanycytes: gatekeepers to metabolic control
Abstract
How circulating signals of hunger and satiety enter the brain to reach neurons that govern energy balance has long remained a matter of controversy and speculation. Balland et al. (2014) now elucidate molecular mechanisms by which a highly specialized hypothalamic glial cell regulates transport of leptin across the blood-brain barrier.
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment on
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Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain.Cell Metab. 2014 Feb 4;19(2):293-301. doi: 10.1016/j.cmet.2013.12.015. Cell Metab. 2014. PMID: 24506870 Free PMC article.
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