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Comment
. 2014 Feb 4;19(2):178-80.
doi: 10.1016/j.cmet.2014.01.005.

NAD+ deficiency in age-related mitochondrial dysfunction

Tomas A Prolla  1 , John M Denu  2
Affiliations
Free article
Comment

NAD+ deficiency in age-related mitochondrial dysfunction

Tomas A Prolla et al. Cell Metab. .
Free article

Abstract

Age-related mitochondrial dysfunction is thought to contribute to mammalian aging, particularly in postmitotic tissues that rely heavily on oxidative phosphorylation. A new study (Gomes et al., 2013) shows that reduced levels of nicotinamide adenine dinucleotide (NAD(+)) contribute to the mitochondrial decay associated with skeletal muscle aging and that sirtuin 1 (SIRT1) modulates this process.

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