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Comment
. 2014 Feb 6;14(2):133-4.
doi: 10.1016/j.stem.2014.01.010.

Turning reactive glia into functional neurons in the brain

Jianfeng Lu  1 , Robert A Bradley  1 , Su-Chun Zhang  2
Affiliations
Comment

Turning reactive glia into functional neurons in the brain

Jianfeng Lu et al. Cell Stem Cell. .

Erratum in

  • Cell Stem Cell. 2014 May 1;14(5):689

Abstract

Following brain injury, reactive glial cells can create scars that inhibit neural repair responses. In this issue of Cell Stem Cell, Guo et al. report that overexpression of NeuroD1 in vivo can directly reprogram reactive glial cells into glutamatergic and GABAergic neurons that integrate into the host's neural circuitry.

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Figures

Figure 1
Figure 1. Direct Conversion of Reactive Glial Cells to Active Neurons Via NeuroD1 Expression
Cortical reactive astrocytes and NG2 glial cells in stab-wound and Alzheimer’s (5XFAD) mouse models are directly converted to electrophysiologically active neurons by retroviral delivery of NeuroD1 invivo. Astrocytes are capable of becoming glutaminergic neurons while NG2 glial cells are capable of converting into both glutaminergic and GABAergic neurons.
See this image and copyright information in PMC

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