Girl power: estrogen promotes HSC self-renewal
- PMID: 24506879
- PMCID: PMC3974548
- DOI: 10.1016/j.stem.2014.01.016
Girl power: estrogen promotes HSC self-renewal
Abstract
Although some hematopoietic cell types are known to respond to sex hormones, hematopoietic stem cells (HSCs) are generally thought to function similarly in both sexes. Recently in Nature, Nakada et al. (2014) show that HSCs respond to higher levels of estrogen in females, resulting in enhanced self-renewal and increased erythropoiesis.
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment on
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Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy.Nature. 2014 Jan 23;505(7484):555-8. doi: 10.1038/nature12932. Nature. 2014. PMID: 24451543 Free PMC article.
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