Expression and significance of MMP3 in synovium of knee joint at different stage in osteoarthritis patients
- PMID: 24507680
- DOI: 10.1016/S1995-7645(14)60042-0
Expression and significance of MMP3 in synovium of knee joint at different stage in osteoarthritis patients
Abstract
Objective: To investigate the expression and significance of MMP-3 in synovium of knee joint at different stage in osteoarthritis (OA) patients.
Methods: Knee synovial tissue were collected in 90 OA patients (the OA group). Patients in the OA group was divided into 3 subgroups: grade I subgroup (n=30), grade II subgroup (n=30), grade III; subgroup (n=30). Thirty patients served as control group. Immunohistochemical assay was used to detect the expression of MMP-3 protein in the knee synovial tissue.
Results: MMP-3 protein was detected in all knee synovial tissue. The expression of MMP-3 protein in the OA group was significantly higher that in the normal synovium (P<0.05), and the MMP-3 protein was mainly located in the cytoplasm. There was significant difference in the expression of MMP-3 protein between the grade I subgroup and the grade II, grade III subgroups (all P<0.05). The expression of MMP-3 protein was positively related to the severity of OA (r=0.912, P<0.05).
Conclusions: The expression of MMP-3 protein are closely related to pathogenic mechanism of OA. It may be an important indicator of early diagnosis and the activity of the disease of osteoarthritis.
Keywords: Immunohistochemical; MMP-3; Osteoarthritis.
Copyright © 2014 Hainan Medical College. Published by Elsevier B.V. All rights reserved.
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