Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Mar;34(1):167-85, viii.
doi: 10.1016/j.cll.2013.11.012.

Methodologies for measurement of cardiac markers

Patrick M Sluss  1
Affiliations
Review

Methodologies for measurement of cardiac markers

Patrick M Sluss. Clin Lab Med. 2014 Mar.

Abstract

Antibody-based tests are the primary technology used for clinical measurement of cardiac biomarkers in peripheral circulation. This article focuses on the principles of immunometric methods that have been applied to cardiac biomarkers of widespread clinical utility (CKMB, Troponins, and B-type natriuretic proteins) and of more recent clinical testing (ST2, Galectin-2, and myosin binding protein C). How these principles are applied in the design of immunometric assays and how they influence assay performance in quantifying cardiac biomarkers in biologic fluids (serum or plasma) is discussed.

Keywords: Assay design; Assay principles; Biomarkers; CKMB; Cardiac markers; Immunoassay; Laboratory medicine; Troponins.

PubMed Disclaimer

LinkOut - more resources