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Review
. 2014 Apr;25(2):107-13.
doi: 10.1016/j.cytogfr.2014.01.001. Epub 2014 Jan 10.

New roles for the BLyS/BAFF family in antigen-experienced B cell niches

Radhika Goenka  1 , Jean L Scholz  2 , Vishal J Sindhava  3 , Michael P Cancro  4
Affiliations
Review

New roles for the BLyS/BAFF family in antigen-experienced B cell niches

Radhika Goenka et al. Cytokine Growth Factor Rev. 2014 Apr.

Abstract

BLyS family members govern selection and survival of cells in the pre-immune B cell compartment, and emerging evidence suggests similar roles in antigen-experienced B cell pools. We review the features of this family, with particular emphasis on recent findings of how BLyS influences affinity maturation in germinal centers, which lie at the intersection of the pre-immune and antigen-experienced B cell compartments. We propose a model whereby tolerogenic selection at the transitional stage and affinity maturation in the germinal center employ the same BLyS driven mechanism.

Keywords: BAFF; BLyS; Germinal center; TACI.

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Figures

Figure 1
Figure 1
Systemic BLyS levels afford survival of only B cells with sub-threshold BCR signals at the transitional checkpoint (left), while TFH-produced BLyS selectively spares antigen-presenting GC B cells with very strong BCR signals (right).
See this image and copyright information in PMC

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