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Review
. 2014 Apr 17:565:7-13.
doi: 10.1016/j.neulet.2014.01.055. Epub 2014 Feb 6.

Role of GFAP in CNS injuries

Michael Brenner  1
Affiliations
Review

Role of GFAP in CNS injuries

Michael Brenner. Neurosci Lett. .

Abstract

The role of GFAP in CNS injury is reviewed as revealed by studies using GFAP null mice. In order to provide background information for these studies, the effects of absence of GFAP in the uninjured astrocyte are also described. Activities attributable to GFAP include suppressing neuronal proliferation and neurite extension in the mature brain, forming a physical barrier to isolate damaged tissue, regulating blood flow following ischemia, contributing to the blood-brain barrier, supporting myelination, and providing mechanical strength. However, findings for many of these roles have been variable among laboratories, pointing to the presence of unappreciated complexity in GFAP function. One complexity may be regional differences in GFAP activities; others are yet to be discovered.

Keywords: Astrocyte; CNS injury; GFAP; Ischemia; Neurotrauma; Reactive gliosis.

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References

    1. Eng LF, Ghirnikar RS. GFAP and astrogliosis. Brain Pathol. 1994;4:229–237. - PubMed
    1. Pekny M, Wilhelmsson U, Pekna M. The dual role of astrocyte activation and reactive gliosis. Neurosci Lett. 2014 this issue. - PubMed
    1. Messing A, Head MW, Galles K, Galbreath EJ, Goldman JE, Brenner M. Fatal encephalopathy with astrocyte inclusions in GFAP transgenic mice. Am J Pathol. 1998;152:391–398. - PMC - PubMed
    1. Brenner M, Goldman JE, Quinlan RA, Messing A. Astrocytes in (patho)physiology of the nervous system. In: Parpura V, Haydon P, editors. Alexander disease: a genetic disorder of astrocytes. Chapter 24. Springer; New York, NY: 2009. pp. 591–648.
    1. Weinstein DE, Shelanski ML, Liem RK. Suppression by antisense mRNA demonstrates a requirement for the glial fibrillary acidic protein in the formation of stable astrocytic processes in response to neurons. J Cell Biol. 1991;112:1205–1213. - PMC - PubMed

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