Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance

Affiliations

¹ Queensland Paediatric Infectious Diseases Laboratory and Queensland Children's Medical Research Institute, Royal Children's Hospital, The University of Queensland, Brisbane, Queensland 4029, Australia.
² WHO Collaborating Centre for Sexually Transmitted Diseases and HIV, Microbiology Department, South Eastern Area Laboratory Services, Prince of Wales Hospital, Sydney, New South Wales 2031, Australia.
³ Melbourne Sexual Health Centre, Alfred Health, Carlton Victoria 3053, Australia and Melbourne School of Population Health, University of Melbourne, Victoria 3010, Australia.
⁴ 1] Kirby Institute, University of New South Wales, Sydney, New South Wales 2052, Australia. [2] Sydney Sexual Health Centre, Sydney Hospital, Sydney New South Wales 2000, Australia.
⁵ Kirby Institute, University of New South Wales, Sydney, New South Wales 2052, Australia.
⁶ Baker IDI Central Australia, Alice Springs, Northern Territory 0870, Australia.
⁷ 1] Queensland Paediatric Infectious Diseases Laboratory and Queensland Children's Medical Research Institute, Royal Children's Hospital, The University of Queensland, Brisbane, Queensland 4029, Australia. [2] Microbiology Division, Pathology Queensland Central, Royal Brisbane and Women's Hospital Campus, Queensland 4006, Australia.

PMID: 24509781
DOI: 10.1038/nrmicro3217

Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance

Namraj Goire et al. Nat Rev Microbiol. 2014 Mar.

. 2014 Mar;12(3):223-9.

doi: 10.1038/nrmicro3217. Epub 2014 Feb 10.

Authors

Affiliations

¹ Queensland Paediatric Infectious Diseases Laboratory and Queensland Children's Medical Research Institute, Royal Children's Hospital, The University of Queensland, Brisbane, Queensland 4029, Australia.
² WHO Collaborating Centre for Sexually Transmitted Diseases and HIV, Microbiology Department, South Eastern Area Laboratory Services, Prince of Wales Hospital, Sydney, New South Wales 2031, Australia.
³ Melbourne Sexual Health Centre, Alfred Health, Carlton Victoria 3053, Australia and Melbourne School of Population Health, University of Melbourne, Victoria 3010, Australia.
⁴ 1] Kirby Institute, University of New South Wales, Sydney, New South Wales 2052, Australia. [2] Sydney Sexual Health Centre, Sydney Hospital, Sydney New South Wales 2000, Australia.
⁵ Kirby Institute, University of New South Wales, Sydney, New South Wales 2052, Australia.
⁶ Baker IDI Central Australia, Alice Springs, Northern Territory 0870, Australia.
⁷ 1] Queensland Paediatric Infectious Diseases Laboratory and Queensland Children's Medical Research Institute, Royal Children's Hospital, The University of Queensland, Brisbane, Queensland 4029, Australia. [2] Microbiology Division, Pathology Queensland Central, Royal Brisbane and Women's Hospital Campus, Queensland 4006, Australia.

PMID: 24509781
DOI: 10.1038/nrmicro3217

Abstract

The best available data indicate that the world is heading towards a pandemic of extensively drug-resistant Neisseria gonorrhoeae. At the same time, clinical microbiology laboratories have moved away from using culture-based methods to diagnose gonorrhoea, thus undermining our ability to detect antimicrobial resistance (AMR) using current technologies. In this Opinion article, we discuss the problem of N. gonorrhoeae AMR, particularly emerging resistance to the cephalosporin ceftriaxone, outline current concerns about the surveillance of N. gonorrhoeae AMR and propose the use of molecular methods on a large scale to systematically enhance surveillance.

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References

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1. Br Med J (Clin Res Ed). 1984 Oct 20;289(6451):1032-4 - PubMed

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Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance

Affiliations

Molecular approaches to enhance surveillance of gonococcal antimicrobial resistance

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical