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. 2014 Jun;35(6):5199-203.
doi: 10.1007/s13277-014-1674-x. Epub 2014 Feb 9.

The diagnostic and prognostic value of serum human kallikrein-related peptidases 11 in non-small cell lung cancer

Chun-Hua Xu  1 , Yu Zhang, Li-Ke Yu
Affiliations

The diagnostic and prognostic value of serum human kallikrein-related peptidases 11 in non-small cell lung cancer

Chun-Hua Xu et al. Tumour Biol. 2014 Jun.

Abstract

The aim of this study was to explore the diagnostic and prognostic value of serum human kallikrein-related peptidases 11 (KLK11) level in non-small cell lung cancer (NSCLC). Serum specimens from 138 patients with NSCLC and 40 healthy controls were collected. The concentration of KLK11 was measured by enzyme-linked immunosorbent assay (ELISA). The concentration of KLK11 in NSCLC was significantly higher compared to that in the controls (P<0.01). The serum KLK11 levels decreased with stage, presence of lymph node, and distant metastases, regardless of histology, age, and sex. With a cutoff point of 1.05 ng/ml, KLK11 showed a good diagnostic performance for NSCLC. Univariate analysis revealed that NSCLC patients with serum high KLK11 had a longer overall survival (OS) and progression-free survival (PFS) than those with low KLK11 (HR of 0.36, P=0.002; HR of 0.46, P=0.009). Cox multivariate analysis indicated that KLK11 was an independent prognostic indicator of PFS and OS (HR of 0.53, P=0.042; HR of 0.48, P=0.037). Kaplan-Meier survival curves further confirmed that patients with high KLK11 have longer PFS and OS (P=0.003 and P=0.018, respectively). In conclusion, the measurement of KLK11 might be a useful diagnostic and prognostic test for NSCLC patients.

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Figures

Fig. 1
Fig. 1
Levels of KLK11 in NSCLC. Among 138 NSCLC patients, the serum levels of KLK11 were 2.04 ± 0.86 ng/ml, which were significantly higher than 0.93 ± 0.52 ng/ml in healthy controls (P < 0.01)
Fig. 2
Fig. 2
ROC of KLK11 for the diagnosis of NSCLC. Serum levels of KLK11 among 138 NSCLC patients and 40 healthy controls were determined. The diagnostic potentials of KLK11 were assessed by ROC curves. The AUC value was 0.892
Fig. 3
Fig. 3
Kaplan–Meier survival curves for PFS and OS in patients with KLK11-high and -low NSCLC. Log-rank test determined that the PFS and OS in high KLK11 group were significantly longer than those in the low KLK11 group (P = 0.003; P = 0.018)
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