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Comment
. 2014 Feb 18;111(7):2402-3.
doi: 10.1073/pnas.1324284111. Epub 2014 Feb 7.

Pathway for Parkinson disease

Quyen Q Hoang  1
Affiliations
Comment

Pathway for Parkinson disease

Quyen Q Hoang. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
(A) Cartoon presentation of LRRK2 showing multidomain structure. Termini and predicted domains labeled along approximate domain boundaries. Cartoon of domain structures were rendered using coordinates of homology models built based on other proteins with known structures. The N-terminus region preceding the LRR domain consists of sequence similarity to more than one additional protein–protein interaction domain, including HEAT [Huntingtin, elongation factor 3 (EF3), protein phosphatase 2A (PP2A), and the yeast kinase TOR1] repeats and Ankyrin repeats; however, their boundaries are more difficult to approximate. (B) A simplified drawing of the vesicular endocytosis pathway showing GAK/Hsc70 involvement in uncoating clathrin-coated vesicles. BAG5 might also be involved in the same process by interacting with Hsc70, and Rab7L1 functions in the retromer sorting process. LRRK2 interacts with all three proteins (GAK, BAG5, and Rab7L1); thus, the process of vesicular endocytosis, sorting, recycling, and degradation might be important in the pathogenesis of PD.
See this image and copyright information in PMC

Comment on

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