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. 2013 Dec;16(4):261-8.
doi: 10.5223/pghn.2013.16.4.261. Epub 2013 Dec 31.

Clinical Characteristics of Failure to Thrive in Infant and Toddler: Organic vs. Nonorganic

Suk Dong Yoo  1 , Eun-Ha Hwang  1 , Yeoun Joo Lee  1 , Jae Hong Park  1
Affiliations

Clinical Characteristics of Failure to Thrive in Infant and Toddler: Organic vs. Nonorganic

Suk Dong Yoo et al. Pediatr Gastroenterol Hepatol Nutr. 2013 Dec.

Abstract

Purpose: To investigate the clinical characteristics and outcomes among infants and toddlers with failure to thrive (FTT).

Methods: This retrospective study was done with 123 patients who had visited Pusan National University Children's Hospital during their first two years of life and had received an FTT diagnosis. We compared the clinical characteristics of the patients based on the causes of their FTT and their ages at the time of first hospital visit. We investigated triggering factors, feeding practices, and outcomes in 25 patients with nonorganic FTT (NOFTT).

Results: Eighty cases (65.0%) were NOFTT. The gestational ages, birth weights, and weights at the first visits were significantly lower in patients with organic FTT (OFTT) (p<0.05). Infants who had first visited the clinic at age <6 months had the least z-score. The percentage of patients with severe weight decline was higher in OFTT than in NOFTT (60.0% vs. 17.3%). The z-scores at the follow-up visits were improved after treatment in both of the groups. Preceding infection was the most common triggering factor of NOFTT and persecutory feeding as abnormal behavior of caregiver was observed in 22 cases (88.0%). After treatment with feeding method modification, all patients with NOFTT showed normal growth.

Conclusion: Weight decline is more severe in OFTT patients and in younger patients at the first visit. Infants with FTT can attain normal weight gain growth by treating organic diseases and supplying proper nutrition in OFTT, and by correcting abnormal dietary behavior of caregiver in NOFTT.

Keywords: Failure to thrive; Infant.

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Figures

Fig. 1
Fig. 1
Changes of z-score of weight at birth, first visit and follow-up visit in patients with organic and nonorganic failure to thrive. There was marked decline of z-score at first visit in organic failure to thrive (p<0.001) and improvement of z-score in both groups at follow-up visit, especially in organic failure to thrive (p=0.037).
Fig. 2
Fig. 2
Changes of z-score of weight at birth, first visit and follow-up visit according to age group. There was marked decline of z-score in the patients whose age at first visit was less than 6 months (p<0.001). The patients of this group showed also significant improvement of z-score at follow-up visit (p=0.017).
See this image and copyright information in PMC

References

    1. Cole SZ, Lanham JS. Failure to thrive: an update. Am Fam Physician. 2011;83:829–834. - PubMed
    1. Olsen EM. Failure to thrive: still a problem of definition. Clin Pediatr (Phila) 2006;45:1–6. - PubMed
    1. Olsen EM, Petersen J, Skovgaard AM, Weile B, Jørgensen T, Wright CM. Failure to thrive: the prevalence and concurrence of anthropometric criteria in a general infant population. Arch Dis Child. 2007;92:109–114. - PMC - PubMed
    1. Zenel JA., Jr Failure to thrive: a general pediatrician's perspective. Pediatr Rev. 1997;18:371–378. - PubMed
    1. Emond A, Drewett R, Blair P, Emmett P. Postnatal factors associated with failure to thrive in term infants in the Avon Longitudinal Study of Parents and Children. Arch Dis Child. 2007;92:115–119. - PMC - PubMed