Review

. 2014 Mar 1;344(1):13-19.

doi: 10.1016/j.canlet.2013.10.015.

Humanized NOD-SCID IL2rg–/– mice as a preclinical model for cancer research and its potential use for individualized cancer therapies

Qianjun Zhou¹, John Facciponte², Min Jin³, Qiang Shen⁴, Qiang Lin⁵

Affiliations

¹ Department of Thoracic Surgery, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China. Electronic address: qianjunzhou@yahoo.com.
² Department of Microbiology and Immunology, State University of New York at Buffalo, Buffalo, NY, United States.
³ Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and SJTUSM, Shanghai, China.
⁴ Department of Clinical Cancer Prevention, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
⁵ Department of Thoracic Surgery, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China. Electronic address: xkliniang@hotmail.com.

PMID: 24513265
DOI: 10.1016/j.canlet.2013.10.015

Review

Humanized NOD-SCID IL2rg–/– mice as a preclinical model for cancer research and its potential use for individualized cancer therapies

Qianjun Zhou et al. Cancer Lett. 2014.

. 2014 Mar 1;344(1):13-19.

doi: 10.1016/j.canlet.2013.10.015.

Authors

Qianjun Zhou¹, John Facciponte², Min Jin³, Qiang Shen⁴, Qiang Lin⁵

Affiliations

¹ Department of Thoracic Surgery, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China. Electronic address: qianjunzhou@yahoo.com.
² Department of Microbiology and Immunology, State University of New York at Buffalo, Buffalo, NY, United States.
³ Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and SJTUSM, Shanghai, China.
⁴ Department of Clinical Cancer Prevention, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
⁵ Department of Thoracic Surgery, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China. Electronic address: xkliniang@hotmail.com.

PMID: 24513265
DOI: 10.1016/j.canlet.2013.10.015

Abstract

Humanized mouse models have been developed and utilized in cancer research for decades. Newly developed combined immunodeficient NOD-SCID-IL2rg–/– mice are more permissive for human cells and tissue engraftment. In this review, we discuss the use of NOD-SCID-IL2rg(–/–) mice as a preclinical tool in cancer research and its potential use for individualized cancer therapies.

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Humanized NOD-SCID IL2rg–/– mice as a preclinical model for cancer research and its potential use for individualized cancer therapies

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Humanized NOD-SCID IL2rg–/– mice as a preclinical model for cancer research and its potential use for individualized cancer therapies

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