. 2014 Oct;19(10):1085-94.

doi: 10.1038/mp.2013.187. Epub 2014 Feb 11.

A genome-wide association study of anorexia nervosa

V Boraska¹, C S Franklin², J A B Floyd³, L M Thornton⁴, L M Huckins², L Southam², N W Rayner⁵, I Tachmazidou², K L Klump⁶, J Treasure⁷, C M Lewis⁸, U Schmidt⁷, F Tozzi⁴, K Kiezebrink⁹, J Hebebrand¹⁰, P Gorwood¹¹, R A H Adan¹², M J H Kas¹³, A Favaro¹⁴, P Santonastaso¹⁴, F Fernández-Aranda¹⁵, M Gratacos¹⁶, F Rybakowski¹⁷, M Dmitrzak-Weglarz¹⁸, J Kaprio¹⁹, A Keski-Rahkonen²⁰, A Raevuori²¹, E F Van Furth²², M C T Slof-Op 't Landt²³, J I Hudson²⁴, T Reichborn-Kjennerud²⁵, G P S Knudsen²⁶, P Monteleone²⁷, A S Kaplan²⁸, A Karwautz²⁹, H Hakonarson³⁰, W H Berrettini³¹, Y Guo³², D Li³², N J Schork³³, G Komaki³⁴, T Ando³⁵, H Inoko³⁶, T Esko³⁷, K Fischer³⁷, K Männik³⁸, A Metspalu³⁹, J H Baker⁴, R D Cone⁴⁰, J Dackor⁴¹, J E DeSocio⁴², C E Hilliard⁴, J K O'Toole⁴³, J Pantel⁴⁴, J P Szatkiewicz⁴¹, C Taico⁴, S Zerwas⁴, S E Trace⁴, O S P Davis⁴⁵, S Helder⁸, K Bühren⁴⁶, R Burghardt⁴⁷, M de Zwaan⁴⁸, K Egberts⁴⁹, S Ehrlich⁵⁰, B Herpertz-Dahlmann⁴⁶, W Herzog⁵¹, H Imgart⁵², A Scherag⁵³, S Scherag¹⁰, S Zipfel⁵⁴, C Boni⁵⁵, N Ramoz⁵⁵, A Versini⁵⁵, M K Brandys¹², U N Danner⁵⁶, C de Kovel⁵⁷, J Hendriks¹³, B P C Koeleman⁵⁷, R A Ophoff⁵⁸, E Strengman⁵⁷, A A van Elburg⁵⁹, A Bruson⁶⁰, M Clementi⁶⁰, D Degortes¹⁴, M Forzan⁶⁰, E Tenconi¹⁴, E Docampo¹⁶, G Escaramís¹⁶, S Jiménez-Murcia¹⁵, J Lissowska⁶¹, A Rajewski⁶², N Szeszenia-Dabrowska⁶², A Slopien¹⁸, J Hauser¹⁸, L Karhunen⁶³, I Meulenbelt⁶⁴, P E Slagboom⁶⁵, A Tortorella⁶⁶, M Maj⁶⁶, G Dedoussis⁶⁷, D Dikeos⁶⁸, F Gonidakis⁶⁹, K Tziouvas⁶⁷, A Tsitsika⁷⁰, H Papezova⁷¹, L Slachtova⁷², D Martaskova⁷¹, J L Kennedy²⁸, R D Levitan²⁸, Z Yilmaz⁷³, J Huemer²⁹, D Koubek²⁹, E Merl²⁹, G Wagner²⁹, P Lichtenstein⁷⁴, G Breen⁸, S Cohen-Woods⁸, A Farmer⁸, P McGuffin⁸, S Cichon⁷⁵, I Giegling⁷⁶, S Herms⁷⁷, D Rujescu⁷⁶, S Schreiber⁷⁸, H-E Wichmann⁷⁹, C Dina⁸⁰, R Sladek⁸¹, G Gambaro⁸², N Soranzo², A Julia⁸³, S Marsal⁸³, R Rabionet¹⁶, V Gaborieau⁸⁴, D M Dick⁸⁵, A Palotie⁸⁶, S Ripatti⁸⁷, E Widén⁸⁷, O A Andreassen⁸⁸, T Espeseth⁸⁹, A Lundervold⁹⁰, I Reinvang⁹¹, V M Steen⁹², S Le Hellard⁹², M Mattingsdal⁸⁸, I Ntalla⁶⁷, V Bencko⁹³, L Foretova⁹⁴, V Janout⁹⁵, M Navratilova⁹⁴, S Gallinger⁹⁶, D Pinto⁹⁷, S W Scherer⁹⁸, H Aschauer⁹⁹, L Carlberg⁹⁹, A Schosser⁹⁹, L Alfredsson¹⁰⁰, B Ding¹⁰⁰, L Klareskog¹⁰¹, L Padyukov¹⁰¹, P Courtet¹⁰², S Guillaume¹⁰², I Jaussent¹⁰², C Finan², G Kalsi⁸, M Roberts⁸, D W Logan², L Peltonen², G R S Ritchie¹⁰³, J C Barrett²; Wellcome Trust Case Control Consortium 3; X Estivill¹⁶, A Hinney¹⁰, P F Sullivan¹⁰⁴, D A Collier¹⁰⁵, E Zeggini², C M Bulik¹⁰⁶

Collaborators, Affiliations

Collaborators

Wellcome Trust Case Control Consortium 3:
Carl A Anderson, Jeffrey C Barrett, James A B Floyd, Christopher S Franklin, Ralph McGinnis, Nicole Soranzo, Eleftheria Zeggini, Jennifer Sambrook, Jonathan Stephens, Willem H Ouwehand, Wendy L McArdle, Susan M Ring, David P Strachan, Graeme Alexander, Cynthia M Bulik, David A Collier, Peter J Conlon, Anna Dominiczak, Audrey Duncanson, Adrian Hill, Cordelia Langford, Graham Lord, Alexander P Maxwell, Linda Morgan, Leena Peltonen, Richard N Sandford, Neil Sheerin, Nicole Soranzo, Fredrik O Vannberg, Jeffrey C Barrett, Hannah Blackburn, Wei-Min Chen, Sarah Edkins, Mathew Gillman, Emma Gray, Sarah E Hunt, Cordelia Langford, Suna Onengut-Gumuscu, Simon Potter, Stephen S Rich, Douglas Simpkin, Pamela Whittaker

Affiliations

¹ 1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK [2] University of Split School of Medicine, Split, Croatia.
² Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
³ 1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK [2] William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, UK.
⁴ Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
⁵ 1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK [2] Wellcome Trust Centre for Human Genetics (WTCHG), University of Oxford, Oxford, UK [3] Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Oxford, UK.
⁶ Department of Psychology, Michigan State University, East Lansing, MI, USA.
⁷ Section of Eating Disorders, Institute of Psychiatry, King's College London, London, UK.
⁸ Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
⁹ Health Services Research Unit, University of Aberdeen, Aberdeen, UK.
¹⁰ Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Universitätsklinikum Essen, University of Duisburg-Essen, Essen, Germany.
¹¹ 1] INSERM U894, Centre of Psychiatry and Neuroscience, Paris, France [2] Sainte-Anne Hospital (CMME), University of Paris-Descartes, Paris, France.
¹² 1] Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands [2] Altrecht Eating Disorders Rintveld, Zeist, The Netherlands.
¹³ Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.
¹⁴ Department of Neurosciences, University of Padova, Padova, Italy.
¹⁵ 1] Department of Psychiatry and CIBERON, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain [2] Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain.
¹⁶ 1] Genomics and Disease Group, Centre for Genomic Regulation (CRG), Barcelona, Spain [2] Universitat Pompeu Fabra (UPF), Barcelona, Spain [3] Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain [4] Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
¹⁷ Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Neurology, Warsaw, Poland.
¹⁸ Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
¹⁹ 1] Hjelt Institute, University of Helsinki, Helsinki, Finland [2] Institute of Molecular Medicine, University of Helsinki, Helsinki, Finland [3] Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland.
²⁰ Hjelt Institute, University of Helsinki, Helsinki, Finland.
²¹ 1] Hjelt Institute, University of Helsinki, Helsinki, Finland [2] Department of Adolescent Psychiatry, Helsinki University Central Hospital, Helsinki, Finland.
²² 1] Center for Eating Disorders Ursula, Leidschendam, The Netherlands [2] Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands.
²³ 1] Center for Eating Disorders Ursula, Leidschendam, The Netherlands [2] Molecular Epidemiology Section, Department of Medical Statistics, Leiden University Medical Centre, Leiden, The Netherlands.
²⁴ Department of Psychiatry, McLean Hospital/Harvard Medical School, Belmont, MA, USA.
²⁵ 1] Department of Genetics, Environment and Mental Health, Norwegian Institute of Public Health, Oslo, Norway [2] Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
²⁶ Department of Genetics, Environment and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.
²⁷ 1] Department of Psychiatry, University of Naples SUN, Naples, Italy [2] Chair of Psychiatry, University of Salerno, Salerno, Italy.
²⁸ 1] Centre for Addiction and Mental Health, Toronto, ON, Canada [2] Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
²⁹ Eating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.
³⁰ 1] The Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA [2] The Division of Human Genetics, Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
³¹ Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
³² The Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
³³ Department of Molecular and Experimental Medicine and The Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, CA, USA.
³⁴ 1] Department of Psychosomatic Research, National Institute of Mental Health, NCNP, Tokyo, Japan [2] School of Health Sciences at Fukuoka, International University of Health and Welfare, Fukuoka, Japan.
³⁵ Department of Psychosomatic Research, National Institute of Mental Health, NCNP, Tokyo, Japan.
³⁶ Department of Molecular Life Sciences, Tokai University School of Medicine, Kanagawa, Japan.
³⁷ Estonian Genome Center, University of Tartu, Tartu, Estonia.
³⁸ 1] Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia [2] Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
³⁹ 1] Estonian Genome Center, University of Tartu, Tartu, Estonia [2] Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
⁴⁰ Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.
⁴¹ Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
⁴² Seattle University College of Nursing, Seattle, WA, USA.
⁴³ Kartini Clinic, Portland, OR, USA.
⁴⁴ Centre de Psychiatrie et Neurosciences - Inserm U894, Paris, France.
⁴⁵ 1] Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK [2] Department of Genetics, Evolution and Environment, University College London, UCL Genetics Institute, London, UK.
⁴⁶ Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Clinics RWTH Aachen, Aachen, Germany.
⁴⁷ Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité, Berlin, Germany.
⁴⁸ 1] Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany [2] Department of Psychosomatic Medicine and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany.
⁴⁹ Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Würzburg, Würzburg, Germany.
⁵⁰ 1] Department of Child and Adolescent Psychiatry, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany [2] Athinoula A. Martinos Center for Biomedical Imaging, Psychiatric Neuroimaging Research Program, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA, USA.
⁵¹ Departments of Psychosocial and Internal Medicine, Heidelberg University, Heidelberg, Germany.
⁵² Parklandklinik, Bad Wildungen, Germany.
⁵³ Institute for Medical Informatics, Biometry and Epidemiology, Universitätsklinikum Essen, University of Duisburg-Essen, Essen, Germany.
⁵⁴ Department of Internal Medicine VI, Psychosomatic Medicine and Psychotherapy, University Medical Hospital Tübingen, Tübingen, Germany.
⁵⁵ INSERM U894, Centre of Psychiatry and Neuroscience, Paris, France.
⁵⁶ Altrecht Eating Disorders Rintveld, Zeist, The Netherlands.
⁵⁷ Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
⁵⁸ 1] Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA [2] Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
⁵⁹ 1] Altrecht Eating Disorders Rintveld, Zeist, The Netherlands [2] Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
⁶⁰ Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Padova, Italy.
⁶¹ M. Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland.
⁶² Department of Epidemiology, Institute of Occupational Medicine, Department of Epidemiology, Lodz, Poland.
⁶³ Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
⁶⁴ Molecular Epidemiology Section, Department of Medical Statistics, Leiden University Medical Centre, Leiden, The Netherlands.
⁶⁵ 1] Molecular Epidemiology Section, Department of Medical Statistics, Leiden University Medical Centre, Leiden, The Netherlands [2] Netherlands Consortium for Healthy Ageing, Leiden University Medical Center, Leiden, The Netherlands.
⁶⁶ Department of Psychiatry, University of Naples SUN, Naples, Italy.
⁶⁷ Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
⁶⁸ 1st Department of Psychiatry, Athens University Medical School, Athens, Greece.
⁶⁹ Eating Disorders Unit, 1st Department of Psychiatry, Athens University Medical School, Athens, Greece.
⁷⁰ Adolescent Health Unit (A.H.U.), 2nd Department of Pediatrics - Medical School, University of Athens 'P. & A. Kyriakou' Children's Hospital, Athens, Greece.
⁷¹ Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
⁷² Department of Pediatrics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
⁷³ 1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Centre for Addiction and Mental Health, Toronto, ON, Canada.
⁷⁴ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
⁷⁵ 1] Department of Genomics, Life & Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany [2] Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany [3] Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.
⁷⁶ Klinikum der Medizinischen Fakultät, Martin-Luther-Universität Halle-Wittenberg, Halle/Saale, Germany.
⁷⁷ 1] Department of Genomics, Life & Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany [2] Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.
⁷⁸ Institute of Clinical Molecular Biology, University of Kiel, Kiel, Germany.
⁷⁹ 1] Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany [2] Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University, Munich, Germany.
⁸⁰ CNRS 8090-Institute of Biology, Pasteur Institute, Lille, France.
⁸¹ McGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada.
⁸² Division of Nephrology, Department of Internal Medicine and Medical Specialties, Columbus-Gemelly Hospitals, Catholic University, Rome, Italy.
⁸³ Unitat de Recerca de Reumatologia (URR), Institut de Recerca Hospital Universitari Vall d'Hebron, Barcelona, Spain.
⁸⁴ Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon, France.
⁸⁵ Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
⁸⁶ 1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK [2] The Finnish Institute of Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [3] The Program for Human and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁸⁷ 1] The Finnish Institute of Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Finnish Institute of Occupational Health, Helsinki, Finland.
⁸⁸ NORMENT, K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
⁸⁹ 1] NORMENT, K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway [2] Department of Psychology, University of Oslo, Oslo, Norway.
⁹⁰ 1] Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway [2] Kavli Research Centre for Aging and Dementia, Haraldsplass Deaconess Hospital, Bergen, Norway [3] K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway.
⁹¹ Department of Psychology, University of Oslo, Oslo, Norway.
⁹² 1] Department of Clinical Science, K.G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), University of Bergen, Bergen, Norway [2] Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
⁹³ Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
⁹⁴ Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
⁹⁵ Palacky University, Olomouc, Czech Republic.
⁹⁶ 1] University Health Network, Toronto General Hospital, Toronto, ON, Canada [2] Mount Sinai Hospital, Samuel Lunenfeld Research Institute, Toronto, ON, Canada.
⁹⁷ Departments of Psychiatry, and Genetics and Genomic Sciences, Seaver Autism Center, and the Mindich Child Health and Development Institute, Mount Sinai School of Medicine, New York, NY, USA.
⁹⁸ The Centre for Applied Genomics and Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
⁹⁹ Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
¹⁰⁰ The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
¹⁰¹ Rheumatology Unit, Department of Medicine at the Karolinska University Hospital, Solna, Sweden.
¹⁰² 1] Inserm, U1061, Université Montpellier 1, Montpellier, France [2] Department of Emergency Psychiatry, CHU Montpellier, Montpellier, France.
¹⁰³ 1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK [2] European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge.
¹⁰⁴ 1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
¹⁰⁵ 1] Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK [2] Eli Lilly and Company, Erl Wood Manor, Windlesham, UK.
¹⁰⁶ 1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Department of Nutrition, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

PMID: 24514567
PMCID: PMC4325090
DOI: 10.1038/mp.2013.187

A genome-wide association study of anorexia nervosa

V Boraska et al. Mol Psychiatry. 2014 Oct.

. 2014 Oct;19(10):1085-94.

doi: 10.1038/mp.2013.187. Epub 2014 Feb 11.

Authors

Collaborators

Wellcome Trust Case Control Consortium 3:
Carl A Anderson, Jeffrey C Barrett, James A B Floyd, Christopher S Franklin, Ralph McGinnis, Nicole Soranzo, Eleftheria Zeggini, Jennifer Sambrook, Jonathan Stephens, Willem H Ouwehand, Wendy L McArdle, Susan M Ring, David P Strachan, Graeme Alexander, Cynthia M Bulik, David A Collier, Peter J Conlon, Anna Dominiczak, Audrey Duncanson, Adrian Hill, Cordelia Langford, Graham Lord, Alexander P Maxwell, Linda Morgan, Leena Peltonen, Richard N Sandford, Neil Sheerin, Nicole Soranzo, Fredrik O Vannberg, Jeffrey C Barrett, Hannah Blackburn, Wei-Min Chen, Sarah Edkins, Mathew Gillman, Emma Gray, Sarah E Hunt, Cordelia Langford, Suna Onengut-Gumuscu, Simon Potter, Stephen S Rich, Douglas Simpkin, Pamela Whittaker

Affiliations

¹ 1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK [2] University of Split School of Medicine, Split, Croatia.
² Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
³ 1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK [2] William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, UK.
⁴ Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
⁵ 1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK [2] Wellcome Trust Centre for Human Genetics (WTCHG), University of Oxford, Oxford, UK [3] Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Oxford, UK.
⁶ Department of Psychology, Michigan State University, East Lansing, MI, USA.
⁷ Section of Eating Disorders, Institute of Psychiatry, King's College London, London, UK.
⁸ Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK.
⁹ Health Services Research Unit, University of Aberdeen, Aberdeen, UK.
¹⁰ Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Universitätsklinikum Essen, University of Duisburg-Essen, Essen, Germany.
¹¹ 1] INSERM U894, Centre of Psychiatry and Neuroscience, Paris, France [2] Sainte-Anne Hospital (CMME), University of Paris-Descartes, Paris, France.
¹² 1] Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands [2] Altrecht Eating Disorders Rintveld, Zeist, The Netherlands.
¹³ Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.
¹⁴ Department of Neurosciences, University of Padova, Padova, Italy.
¹⁵ 1] Department of Psychiatry and CIBERON, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain [2] Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain.
¹⁶ 1] Genomics and Disease Group, Centre for Genomic Regulation (CRG), Barcelona, Spain [2] Universitat Pompeu Fabra (UPF), Barcelona, Spain [3] Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain [4] Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
¹⁷ Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Neurology, Warsaw, Poland.
¹⁸ Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
¹⁹ 1] Hjelt Institute, University of Helsinki, Helsinki, Finland [2] Institute of Molecular Medicine, University of Helsinki, Helsinki, Finland [3] Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland.
²⁰ Hjelt Institute, University of Helsinki, Helsinki, Finland.
²¹ 1] Hjelt Institute, University of Helsinki, Helsinki, Finland [2] Department of Adolescent Psychiatry, Helsinki University Central Hospital, Helsinki, Finland.
²² 1] Center for Eating Disorders Ursula, Leidschendam, The Netherlands [2] Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands.
²³ 1] Center for Eating Disorders Ursula, Leidschendam, The Netherlands [2] Molecular Epidemiology Section, Department of Medical Statistics, Leiden University Medical Centre, Leiden, The Netherlands.
²⁴ Department of Psychiatry, McLean Hospital/Harvard Medical School, Belmont, MA, USA.
²⁵ 1] Department of Genetics, Environment and Mental Health, Norwegian Institute of Public Health, Oslo, Norway [2] Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
²⁶ Department of Genetics, Environment and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.
²⁷ 1] Department of Psychiatry, University of Naples SUN, Naples, Italy [2] Chair of Psychiatry, University of Salerno, Salerno, Italy.
²⁸ 1] Centre for Addiction and Mental Health, Toronto, ON, Canada [2] Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
²⁹ Eating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.
³⁰ 1] The Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA [2] The Division of Human Genetics, Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
³¹ Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.
³² The Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
³³ Department of Molecular and Experimental Medicine and The Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, CA, USA.
³⁴ 1] Department of Psychosomatic Research, National Institute of Mental Health, NCNP, Tokyo, Japan [2] School of Health Sciences at Fukuoka, International University of Health and Welfare, Fukuoka, Japan.
³⁵ Department of Psychosomatic Research, National Institute of Mental Health, NCNP, Tokyo, Japan.
³⁶ Department of Molecular Life Sciences, Tokai University School of Medicine, Kanagawa, Japan.
³⁷ Estonian Genome Center, University of Tartu, Tartu, Estonia.
³⁸ 1] Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia [2] Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
³⁹ 1] Estonian Genome Center, University of Tartu, Tartu, Estonia [2] Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
⁴⁰ Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.
⁴¹ Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
⁴² Seattle University College of Nursing, Seattle, WA, USA.
⁴³ Kartini Clinic, Portland, OR, USA.
⁴⁴ Centre de Psychiatrie et Neurosciences - Inserm U894, Paris, France.
⁴⁵ 1] Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK [2] Department of Genetics, Evolution and Environment, University College London, UCL Genetics Institute, London, UK.
⁴⁶ Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Clinics RWTH Aachen, Aachen, Germany.
⁴⁷ Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité, Berlin, Germany.
⁴⁸ 1] Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany [2] Department of Psychosomatic Medicine and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany.
⁴⁹ Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Würzburg, Würzburg, Germany.
⁵⁰ 1] Department of Child and Adolescent Psychiatry, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany [2] Athinoula A. Martinos Center for Biomedical Imaging, Psychiatric Neuroimaging Research Program, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA, USA.
⁵¹ Departments of Psychosocial and Internal Medicine, Heidelberg University, Heidelberg, Germany.
⁵² Parklandklinik, Bad Wildungen, Germany.
⁵³ Institute for Medical Informatics, Biometry and Epidemiology, Universitätsklinikum Essen, University of Duisburg-Essen, Essen, Germany.
⁵⁴ Department of Internal Medicine VI, Psychosomatic Medicine and Psychotherapy, University Medical Hospital Tübingen, Tübingen, Germany.
⁵⁵ INSERM U894, Centre of Psychiatry and Neuroscience, Paris, France.
⁵⁶ Altrecht Eating Disorders Rintveld, Zeist, The Netherlands.
⁵⁷ Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
⁵⁸ 1] Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA [2] Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
⁵⁹ 1] Altrecht Eating Disorders Rintveld, Zeist, The Netherlands [2] Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
⁶⁰ Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Padova, Italy.
⁶¹ M. Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland.
⁶² Department of Epidemiology, Institute of Occupational Medicine, Department of Epidemiology, Lodz, Poland.
⁶³ Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
⁶⁴ Molecular Epidemiology Section, Department of Medical Statistics, Leiden University Medical Centre, Leiden, The Netherlands.
⁶⁵ 1] Molecular Epidemiology Section, Department of Medical Statistics, Leiden University Medical Centre, Leiden, The Netherlands [2] Netherlands Consortium for Healthy Ageing, Leiden University Medical Center, Leiden, The Netherlands.
⁶⁶ Department of Psychiatry, University of Naples SUN, Naples, Italy.
⁶⁷ Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
⁶⁸ 1st Department of Psychiatry, Athens University Medical School, Athens, Greece.
⁶⁹ Eating Disorders Unit, 1st Department of Psychiatry, Athens University Medical School, Athens, Greece.
⁷⁰ Adolescent Health Unit (A.H.U.), 2nd Department of Pediatrics - Medical School, University of Athens 'P. & A. Kyriakou' Children's Hospital, Athens, Greece.
⁷¹ Department of Psychiatry, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
⁷² Department of Pediatrics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
⁷³ 1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Centre for Addiction and Mental Health, Toronto, ON, Canada.
⁷⁴ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
⁷⁵ 1] Department of Genomics, Life & Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany [2] Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany [3] Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.
⁷⁶ Klinikum der Medizinischen Fakultät, Martin-Luther-Universität Halle-Wittenberg, Halle/Saale, Germany.
⁷⁷ 1] Department of Genomics, Life & Brain Center, Institute of Human Genetics, University of Bonn, Bonn, Germany [2] Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.
⁷⁸ Institute of Clinical Molecular Biology, University of Kiel, Kiel, Germany.
⁷⁹ 1] Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany [2] Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University, Munich, Germany.
⁸⁰ CNRS 8090-Institute of Biology, Pasteur Institute, Lille, France.
⁸¹ McGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada.
⁸² Division of Nephrology, Department of Internal Medicine and Medical Specialties, Columbus-Gemelly Hospitals, Catholic University, Rome, Italy.
⁸³ Unitat de Recerca de Reumatologia (URR), Institut de Recerca Hospital Universitari Vall d'Hebron, Barcelona, Spain.
⁸⁴ Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), Lyon, France.
⁸⁵ Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
⁸⁶ 1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK [2] The Finnish Institute of Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [3] The Program for Human and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁸⁷ 1] The Finnish Institute of Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland [2] Finnish Institute of Occupational Health, Helsinki, Finland.
⁸⁸ NORMENT, K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
⁸⁹ 1] NORMENT, K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway [2] Department of Psychology, University of Oslo, Oslo, Norway.
⁹⁰ 1] Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway [2] Kavli Research Centre for Aging and Dementia, Haraldsplass Deaconess Hospital, Bergen, Norway [3] K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway.
⁹¹ Department of Psychology, University of Oslo, Oslo, Norway.
⁹² 1] Department of Clinical Science, K.G. Jebsen Centre for Psychosis Research, Norwegian Centre For Mental Disorders Research (NORMENT), University of Bergen, Bergen, Norway [2] Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
⁹³ Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
⁹⁴ Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
⁹⁵ Palacky University, Olomouc, Czech Republic.
⁹⁶ 1] University Health Network, Toronto General Hospital, Toronto, ON, Canada [2] Mount Sinai Hospital, Samuel Lunenfeld Research Institute, Toronto, ON, Canada.
⁹⁷ Departments of Psychiatry, and Genetics and Genomic Sciences, Seaver Autism Center, and the Mindich Child Health and Development Institute, Mount Sinai School of Medicine, New York, NY, USA.
⁹⁸ The Centre for Applied Genomics and Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
⁹⁹ Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
¹⁰⁰ The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
¹⁰¹ Rheumatology Unit, Department of Medicine at the Karolinska University Hospital, Solna, Sweden.
¹⁰² 1] Inserm, U1061, Université Montpellier 1, Montpellier, France [2] Department of Emergency Psychiatry, CHU Montpellier, Montpellier, France.
¹⁰³ 1] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK [2] European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge.
¹⁰⁴ 1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
¹⁰⁵ 1] Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK [2] Eli Lilly and Company, Erl Wood Manor, Windlesham, UK.
¹⁰⁶ 1] Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA [2] Department of Nutrition, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

PMID: 24514567
PMCID: PMC4325090
DOI: 10.1038/mp.2013.187

Abstract

Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21 080 controls. AN subtype analyses (1606 AN restricting; 1445 AN binge-purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P=3.01 × 10(-7)) in SOX2OT and rs17030795 (P=5.84 × 10(-6)) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P=5.76 × 10(-)(6)) between CUL3 and FAM124B and rs1886797 (P=8.05 × 10(-)(6)) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P=4 × 10(-6)), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: Patrick F. Sullivan was on the SAB of Expression Analysis (Durham, NC).

Cynthia Bulik was a consultant for Shire Pharmaceuticals at the time the manuscript was written.

Federica Tozzi was full time employee of GSK at the time when the study was performed.

David A. Collier was employed by Eli Lilly UK for a portion of the time that this study was performed.

James L. Kennedy has received honoraria from Eli Lilly and Roche.

Robert D. Levitan has received honorarium from Astra-Zeneca.

Figures

**Figure 1**
Analysis of RNAseq data for whole-brain tissue obtained from 12 different mouse strains for 32 mouse orthologues of the 34 human genes for which association to anorexia nervosa (AN) was identified. The average FPKM (Fragments Per Kilobase of exon per Million fragments mapped) values for 32 genes across 12 mouse strains are shown.

See this image and copyright information in PMC

References

1. Klump KL, Bulik CM, Kaye WH, Treasure J, Tyson E. Academy for Eating Disorders position paper: eating disorders are serious mental illnesses. Int J Eat Disord. 2009;42:97–103. - PubMed
1. Hudson JI, Hiripi E, Pope HG, Jr, Kessler RC. The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication. Biol Psychiatry. 2007;61:348–358. - PMC - PubMed
1. Hoek H, van Hoeken D. Review of the prevalence and incidence of eating disorders. Int J Eat Disord. 2003;34:383–396. - PubMed
1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Fourth Edition Text Revision. American Psychiatric Press; Washington, DC: 2000.
1. Lucas AR, Beard CM, O'Fallon WM, Kurland LT. 50-year trends in the incidence of anorexia nervosa in Rochester, Minn.: a population-based study. Am J Psychiatry. 1991;148:917–922. - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

A genome-wide association study of anorexia nervosa

Collaborators

Affiliations

A genome-wide association study of anorexia nervosa

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources