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. 2014 Nov;63(11):1683-4.
doi: 10.1136/gutjnl-2013-306603. Epub 2014 Feb 10.

Chemokines and alcoholic hepatitis: are chemokines good therapeutic targets?

Bin Gao  1 , Mingjiang Xu  1
Affiliations

Chemokines and alcoholic hepatitis: are chemokines good therapeutic targets?

Bin Gao et al. Gut. 2014 Nov.
No abstract available

Keywords: Alcoholic Liver Disease; Chemokines; Inflammation; Inflammatory Mediators; Interleukin 8.

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Figures

Figure 1
Figure 1
A model depicting the roles of CCL20 in alcoholic steatohepatitis. Excessive alcohol drinking results in elevated levels of bacterial products, such as lipopolysaccharides (LPS), in the portal blood. LPS, via targeting TLR4, stimulates Kupffer cells and hepatic stellate cells to produce CCL20. This chemokine activates dendritic cells (DCs) and monocytes/macrophages to produce proinflammatory cytokines by targeting CCR6, leading to liver inflammation.
See this image and copyright information in PMC

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