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Review
. 2013 Jul;18(7):601-10.

Pharmacokinetic drug-drug interaction and their implication in clinical management

Caterina Palleria  1 , Antonello Di Paolo  2 , Chiara Giofrè  1 , Chiara Caglioti  1 , Giacomo Leuzzi  3 , Antonio Siniscalchi  4 , Giovambattista De Sarro  1 , Luca Gallelli  1
Affiliations
Review

Pharmacokinetic drug-drug interaction and their implication in clinical management

Caterina Palleria et al. J Res Med Sci. 2013 Jul.

Abstract

Drug-drug interactions (DDIs) are one of the commonest causes of medication error in developed countries, particularly in the elderly due to poly-therapy, with a prevalence of 20-40%. In particular, poly-therapy increases the complexity of therapeutic management and thereby the risk of clinically important DDIs, which can both induce the development of adverse drug reactions or reduce the clinical efficacy. DDIs can be classify into two main groups: pharmacokinetic and pharmacodynamic. In this review, using Medline, PubMed, Embase, Cochrane library and Reference lists we searched articles published until June 30 2012, and we described the mechanism of pharmacokinetic DDIs focusing the interest on their clinical implications.

Keywords: Absorption; adverse drug reaction; distribution; drug-drug interactions; excretion; metabolism; poly-therapy.

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Conflict of interest statement

Conflict of Interest: None declared.

References

    1. Moore N, Biour M, Paux G, Loupi E, Begaud B, Boismare F, et al. Adverse drug reaction monitoring: Doing it the French way. Lancet. 1985;2:1056–8. - PubMed
    1. Lee CE, Zembower TR, Fotis MA, Postelnick MJ, Greenberger PA, Peterson LR, et al. The incidence of antimicrobial allergies in hospitalized patients: Implications regarding prescribing patterns and emerging bacterial resistance. Arch Intern Med. 2000;160:2819–22. - PubMed
    1. Bordet R, Gautier S, Le Louet H, Dupuis B, Caron J. Analysis of the direct cost of adverse drug reactions in hospitalised patients. Eur J Clin Pharmacol. 2001;56:935–41. - PubMed
    1. Gallelli L, Ferreri G, Colosimo M, Pirritano D, Guadagnino L, Pelaia G, et al. Adverse drug reactions to antibiotics observed in two pulmonology divisions of catanzaro, Italy: A six-year retrospective study. Pharmacol Res. 2002;46:395–400. - PubMed
    1. Gallelli L, Ferreri G, Colosimo M, Pirritano D, Flocco MA, Pelaia G, et al. Retrospective analysis of adverse drug reactions to bronchodilators observed in two pulmonary divisions of Catanzaro, Italy. Pharmacol Res. 2003;47:493–9. - PubMed

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