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Comparative Study
. 1988 Apr 1;167(4):1499-504.
doi: 10.1084/jem.167.4.1499.

VH gene family utilization is regulated by a locus outside of the VH region

G E Wu  1 , C J Paige
Affiliations
Comparative Study

VH gene family utilization is regulated by a locus outside of the VH region

G E Wu et al. J Exp Med. .

Abstract

We have used the RNA colony blot method to examine VH usage in colonies derived from primary splenic B cells. We found that there are strain-specific differences in the pattern of VH usage. Using parental F1, congenic, and recombinant inbred strains we demonstrate that the genetic element that causes the observed phenotype is: (a) stably expressed; (b) not due to maternal influence; (c) not due to dominate diffusible factors; (d) not linked to cloning efficiency; and (e) outside the Igh locus.

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References

    1. J Immunol Methods. 1986 Oct 23;93(1):37-43 - PubMed
    1. EMBO J. 1986 Dec 20;5(13):3475-81 - PubMed
    1. Cell. 1987 Jun 19;49(6):775-83 - PubMed
    1. J Exp Med. 1987 Jul 1;166(1):163-72 - PubMed
    1. Cell. 1986 Nov 7;47(3):461-70 - PubMed

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