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. 1988 May;62(5):1845-8.
doi: 10.1128/JVI.62.5.1845-1848.1988.

Evidence for a complex structure of neutralization antigenic site I of poliovirus type 1 Mahoney

K Wiegers  1 , H Uhlig, R Dernick
Affiliations

Evidence for a complex structure of neutralization antigenic site I of poliovirus type 1 Mahoney

K Wiegers et al. J Virol. 1988 May.

Erratum in

  • J Virol 1988 Oct 1;62(10):3918

Abstract

We have selected neutralization escape mutants by using a monoclonal antibody (nt-MAb) against a sequential epitope between amino acids 93 through 104 (neutralization antigenic site I) of poliovirus type 1 Mahoney. The majority of mutants were also resistant against five strain-specific nt-MAbs which recognized conformation-dependent epitopes, suggesting that the neutralization antigenic site I must be involved in the formation of such epitopes. An analysis of all mutants by the binding of nt-MAbs and by isoelectric focusing of VP1 allowed discrimination of five classes of mutants. Sequence analysis of mutant RNAs revealed point mutations and deletions in the antibody-binding site.

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