STAT3 Activation in Glioblastoma: Biochemical and Therapeutic Implications

Jennifer E Kim¹, Mira Patel², Jacob Ruzevick³, Christopher M Jackson⁴, Michael Lim⁵

Affiliations

¹ Department of Neurosurgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe St., Phipps Building Rm 123, Baltimore, MD 21287, USA. jkim256@jhmi.edu.
² Department of Neurosurgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe St., Phipps Building Rm 123, Baltimore, MD 21287, USA. mpatel50@jhmi.edu.
³ Department of Neurosurgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe St., Phipps Building Rm 123, Baltimore, MD 21287, USA. jruzevick@jhmi.edu.
⁴ Department of Neurosurgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe St., Phipps Building Rm 123, Baltimore, MD 21287, USA. cjacks53@jhmi.edu.
⁵ Department of Neurosurgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe St., Phipps Building Rm 123, Baltimore, MD 21287, USA. mlim3@jhmi.edu.

PMID: 24518612
PMCID: PMC3980601
DOI: 10.3390/cancers6010376

STAT3 Activation in Glioblastoma: Biochemical and Therapeutic Implications

Jennifer E Kim et al. Cancers (Basel). 2014.

. 2014 Feb 10;6(1):376-95.

doi: 10.3390/cancers6010376.

Authors

Jennifer E Kim¹, Mira Patel², Jacob Ruzevick³, Christopher M Jackson⁴, Michael Lim⁵

Affiliations

¹ Department of Neurosurgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe St., Phipps Building Rm 123, Baltimore, MD 21287, USA. jkim256@jhmi.edu.
² Department of Neurosurgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe St., Phipps Building Rm 123, Baltimore, MD 21287, USA. mpatel50@jhmi.edu.
³ Department of Neurosurgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe St., Phipps Building Rm 123, Baltimore, MD 21287, USA. jruzevick@jhmi.edu.
⁴ Department of Neurosurgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe St., Phipps Building Rm 123, Baltimore, MD 21287, USA. cjacks53@jhmi.edu.
⁵ Department of Neurosurgery, The Johns Hopkins University School of Medicine, 600 N. Wolfe St., Phipps Building Rm 123, Baltimore, MD 21287, USA. mlim3@jhmi.edu.

PMID: 24518612
PMCID: PMC3980601
DOI: 10.3390/cancers6010376

Abstract

Signal transducer and activator of transcription 3 (STAT3) is a potent regulator of gliomagenesis through its induction of angiogenesis, host immunosuppression, and tumor invasion. Gain of function mutations result in constitutive activation of STAT3 in glioma cells, making STAT3 an attractive target for inhibition in cancer therapy. Nevertheless, some studies show that STAT3 also participates in terminal differentiation and apoptosis of various cell lines and in glioma with phosphatase and tensin homolog (PTEN)-deficient genetic backgrounds. In light of these findings, the utility of STAT3 as a prognostic indicator and as a target of drug therapies will be contingent on a more nuanced understanding of its pro- and anti-tumorigenic effects.

PubMed Disclaimer

Figures

**Figure 1**
STAT3 as convergence point in the oncogenic pathway.

See this image and copyright information in PMC

Cited by

Targeting Apoptosis and Multiple Signaling Pathways with Icariside II in Cancer Cells.
Khan M, Maryam A, Qazi JI, Ma T. Khan M, et al. Int J Biol Sci. 2015 Jul 16;11(9):1100-12. doi: 10.7150/ijbs.11595. eCollection 2015. Int J Biol Sci. 2015. PMID: 26221076 Free PMC article. Review.
Role of STAT3 in Genesis and Progression of Human Malignant Gliomas.
Ouédraogo ZG, Biau J, Kemeny JL, Morel L, Verrelle P, Chautard E. Ouédraogo ZG, et al. Mol Neurobiol. 2017 Oct;54(8):5780-5797. doi: 10.1007/s12035-016-0103-0. Epub 2016 Sep 22. Mol Neurobiol. 2017. PMID: 27660268 Review.
The role and application of small extracellular vesicles in glioma.
Yang Z, Wu H, Wang Z, Bian E, Zhao B. Yang Z, et al. Cancer Cell Int. 2024 Jun 29;24(1):229. doi: 10.1186/s12935-024-03389-z. Cancer Cell Int. 2024. PMID: 38951882 Free PMC article. Review.
Tracing the origins of glioblastoma by investigating the role of gliogenic and related neurogenic genes/signaling pathways in GBM development: a systematic review.
Shafi O, Siddiqui G. Shafi O, et al. World J Surg Oncol. 2022 May 10;20(1):146. doi: 10.1186/s12957-022-02602-5. World J Surg Oncol. 2022. PMID: 35538578 Free PMC article.
STAT-3 RNAscope Determination in Human Diffuse Large B-Cell Lymphoma.
Tamma R, Ingravallo G, Albano F, Gaudio F, Annese T, Ruggieri S, Lorusso L, Errede M, Maiorano E, Specchia G, Ribatti D. Tamma R, et al. Transl Oncol. 2019 Mar;12(3):545-549. doi: 10.1016/j.tranon.2018.12.008. Epub 2019 Jan 9. Transl Oncol. 2019. PMID: 30639963 Free PMC article.

See all "Cited by" articles

References

1. Ostrom Q.T., Gittleman H., Farah P., Ondracek A., Chen Y., Wolinsky Y., Stroup N.E., Kruchko C., Barnholtz-Sloan J.S. CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the united states in 2006–2010. Neuro-oncology. 2013;15:ii1–ii56. - PMC - PubMed
1. Stewart L.A. Chemotherapy in adult high-grade glioma: A systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet. 2002;359:1011–1018. doi: 10.1016/S0140-6736(02)08091-1. - DOI - PubMed
1. Rich J.N., Reardon D.A., Peery T., Dowell J.M., Quinn J.A., Penne K.L., Wikstrand C.J., van Duyn L.B., Dancey J.E., McLendon R.E., et al. Phase II trial of gefitinib in recurrent glioblastoma. J. Clin. Oncol. 2004;22:133–142. - PubMed
1. Taylor T.E., Furnari F.B., Cavenee W.K. Targeting EGFR for treatment of glioblastoma: Molecular basis to overcome resistance. Curr. Cancer Drug Targets. 2012;12:197–209. doi: 10.2174/156800912799277557. - DOI - PMC - PubMed
1. Mellinghoff I.K., Wang M.Y., Vivanco I., Haas-Kogan D.A., Zhu S., Dia E.Q., Lu K.V., Yoshimoto K., Huang J.H., Chute D.J., et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N. Engl. J. Med. 2005;353:2012–2024. doi: 10.1056/NEJMoa051918. - DOI - PubMed

LinkOut - more resources

Full Text Sources
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations
Research Materials
- NCI CPTC Antibody Characterization Program
Miscellaneous
- NCI CPTAC Assay Portal

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

STAT3 Activation in Glioblastoma: Biochemical and Therapeutic Implications

Affiliations

STAT3 Activation in Glioblastoma: Biochemical and Therapeutic Implications

Authors

Affiliations

Abstract

Figures

Similar articles

Cited by

References

LinkOut - more resources

Full Text Sources

Other Literature Sources

Research Materials

Miscellaneous