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Review
. 2014 Jan;46(1):2-18.
doi: 10.4143/crt.2014.46.1.2. Epub 2014 Jan 15.

Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice

Sahdeo Prasad  1 , Amit K Tyagi  1 , Bharat B Aggarwal  1
Affiliations
Review

Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice

Sahdeo Prasad et al. Cancer Res Treat. 2014 Jan.

Abstract

Curcumin (diferuloylmethane) is a yellow pigment present in the spice turmeric (Curcuma longa) that has been associated with antioxidant, anti-inflammatory, anticancer, antiviral, and antibacterial activities as indicated by over 6,000 citations. In addition, over one hundred clinical studies have been carried out with curcumin. One of the major problems with curcumin is perceived to be the bioavailability. How curcumin should be delivered in vivo, how bioavailable is it, how well curcumin is absorbed and how it is metabolized, is the focus of this review. Various formulations of curcumin that are currently available are also discussed.

Keywords: Anticancer; Biological availability; Curcumin; Metabolism; Nano-formulation.

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Conflict of interest statement

Conflict of interest relevant to this article was not reported.

Figures

Fig. 1
Fig. 1
Various curcumin-based products include capsules, tablets, ointments, energy drinks, soaps, and cosmetics.
Fig. 2
Fig. 2
Redesign of curcumin through various strategies to enhance bioavailability. GMO, glyceryl monoleate; PLGA, polylactic-co-glycolic acid; PHEMA, poly(2-hydroxyethyl methacrylate); PEG-PEI, polyethylene glycol-poly(ethylene imine).
Fig. 3
Fig. 3
Biodistribution of [18F]-curcumin (A) and of [18F]-curcumin co-injected with piperine (B) in mice. Adopted from Ryu et al. [117], J Med Chem. 2006;49:6111-9.
Fig. 4
Fig. 4
Metabolism of curcumin.
See this image and copyright information in PMC

References

    1. Rahman I, Biswas SK, Kirkham PA. Regulation of inflammation and redox signaling by dietary polyphenols. Biochem Pharmacol. 2006;72:1439–1452. - PubMed
    1. Tirkey N, Kaur G, Vij G, Chopra K. Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys. BMC Pharmacol. 2005;5:15. - PMC - PubMed
    1. Gupta SC, Kim JH, Prasad S, Aggarwal BB. Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev. 2010;29:405–434. - PMC - PubMed
    1. Sharma S, Kulkarni SK, Chopra K. Curcumin, the active principle of turmeric (Curcuma longa), ameliorates diabetic nephropathy in rats. Clin Exp Pharmacol Physiol. 2006;33:940–945. - PubMed
    1. Nishiyama T, Mae T, Kishida H, Tsukagawa M, Mimaki Y, Kuroda M, et al. Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. J Agric Food Chem. 2005;53:959–963. - PubMed