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. 2013 Apr;7(1):13-20.
Epub 2013 Mar 6.

Effect of progesterone supplementation on natural frozen-thawed embryo transfer cycles: a randomized controlled trial

Maryam Eftekhar  1 , Mozhgan Rahsepar  1 , Elham Rahmani  2
Affiliations

Effect of progesterone supplementation on natural frozen-thawed embryo transfer cycles: a randomized controlled trial

Maryam Eftekhar et al. Int J Fertil Steril. 2013 Apr.

Abstract

Background: The transfer of cryopreserved embryos can be timed with ovulation in a natural cycle or after artificially preparing the endometrium with exogenous hormones. Progesterone is essential for the secretory transformation of the endometrium that permits implantation as well as maintenance of early pregnancy. The purpose of this study is to assess the effect of luteal phase supplementation on pregnancy rates in natural frozen-thawed cycles.

Materials and methods: The study was designed as a prospective randomized clinical trial of 102 women who underwent embryo transfers in natural cycles. The women in the interventional group (n=51) received intra muscular (IM) progesterone 50 mg twice a day starting from 36 hours after hCG administration. The control group (n=51) did not receive any progesterone support.

Results: There were no significant differences in demographic characteristics between the groups and no statistically significant differences were observed between study and control groups in clinical pregnancy rate (33.3% vs. 27.5%, p=0.66). There were no differences in implantation rate or spontaneous abortion rate.

Conclusion: Our results suggest that luteal phase support does not affect clinical pregnancy rates in natural frozen-thawed embryo transfer cycles (Registration Number: IRCT201108044339N6).

Keywords: Embryo Transfer; Natural Cycle; Pregnancy Rate; Progesterone.

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Figures

Fig 1
Fig 1
Flowchart of study patients
See this image and copyright information in PMC

References

    1. Trounson A, Mohr L. Human pregnancy following cryopreservation, thawing and transfer of an eight-cell embryo. Nature. 1983;305(5936):707–709. - PubMed
    1. Gelbaya TA, Nardo LG, Hunter HR, Fitzgerald CT, Horne G, Pease EE, et al. Cryopreserved-thawed embryo transfer in natural or down-regulated hormonally controlled cycles: a retrospective study. Fertil Steril. 2006;85(3):603–609. - PubMed
    1. Ghobara T, Vandekerckhove P. Cycle regimens for frozenthawed embryo transfer. Cochrane Database Syst Rev. 2008;(1):CD003414–CD003414. - PubMed
    1. Lahav-Baratz S, Koifman M, Shiloh H, Ishai D, Wiener-Megnazi Z, Dirnfeld M. Analyzing factors affecting the success rate of frozen–thawed embryos. J Assist Reprod Genet. 2003;20(11):444–448. - PMC - PubMed
    1. Urman B, Balaban B, Yakin K. Impact of fresh-cycle variables on the implantation potential of cryopreserved-thawed human embryos. Fertil Steril. 2007;87(2):310–315. - PubMed

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