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Case Reports
. 2014 Feb 13;370(7):682-3.
doi: 10.1056/NEJMc1308413.

How a single patient influenced HIV research--15-year follow-up

Heiko Jessen  1 , Todd M Allen, Hendrik Streeck
Affiliations
Case Reports

How a single patient influenced HIV research--15-year follow-up

Heiko Jessen et al. N Engl J Med. .

Abstract

A follow-up report on a patient whose HIV infection was treated early, but briefly, 15 years ago reveals a likely explanation for the control of HIV without antiretroviral therapy.

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Figures

Figure 1
Figure 1. Laboratory Values and Viral Sequences for the Patient
Panel A shows the HIV RNA viral load in plasma and CD4+ count in the patient during 15 years of testing. Panel B shows the patient’s HIV-specific CD8+ T-cell responses against previously defined optimal epitopes as determined with the use of an enzyme-linked immunosorbent spot (ELISPOT) assay for high-resolution frequency analysis of interferon-γ–secreting cells. Responses are displayed as spot-forming cells per million peripheral-blood mononuclear cells (SFC/M). Actual viral sequences in samples obtained from the patient are shown on the right. Bold lettering indicates mutations in the targeted epitope.
See this image and copyright information in PMC

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