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Comment
. 2014 Feb 13;18(1):109.
doi: 10.1186/cc13726.

Fever in sepsis: is it cool to be hot?

Paul J Young, Rinaldo Bellomo
Comment

Fever in sepsis: is it cool to be hot?

Paul J Young et al. Crit Care. .

Abstract

Changes in body temperature are a characteristic feature of sepsis. The study by Kushimoto and colleagues in a recent issue of Critical Care demonstrates that hypothermia is a very important manifestation of infection associated with very high mortality. Combined with recent data suggesting that febrile patients with infections have the lowest mortality risk, the study raises the question of whether inducing therapeutic hyperthermia might be beneficial in this patient group. Body temperature is easily measured and manipulated in the ICU, and interventional trials defining the most appropriate temperature targets in ICU patients with infections are urgently needed. One such study is in progress.

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References

    1. Kushimoto S, Gando S, Saitoh D, Mayumi T, Ogura H, Fujishima S, Araki T, Ikeda H, Kotani J, Miki Y, Shiraishi SI, Suzuki K, Suzuki Y, Takeyama N, Takuma K, Tsuruta R, Yamaguchi Y, Yamashita N, Aikawa N. The impact of body temperature abnormalities on the disease severity and outcome in patients with severe sepsis: an analysis from a multicentre, prospective survey of severe sepsis. Crit Care. 2013;17:R271. - PMC - PubMed
    1. Young PJ, Saxena M, Beasley R, Bellomo R, Bailey M, Pilcher D, Finfer S, Harrison D, Myburgh J, Rowan K. Early peak temperature and mortality in critically ill patients with or without infection. Intensive Care Med. 2012;38:347–444. - PubMed
    1. Clemmer TP, Fisher CJ Jr, Bone RC, Slotman GJ, Metz CA, Thomas FO. Hypothermia in the sepsis syndrome and clinical outcome, The Methylprednisolone Severe Sepsis Study Group. Crit Care Med. 1992;20:1395–1401. - PubMed
    1. Peres Bota D, Lopes Ferreira F, Melot C, Vincent JL. Body temperature alterations in the critically ill. Intensive Care Med. 2004;30:811–816. - PubMed
    1. Wagner-Jauregg J. Nobel Lectures: Physiology or Medicine 1922–1941. New York: Elsevier; 1927. The treatment of dementia paralytica by malaria innoculation; pp. 159–169.